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Letter | Open Access

Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort

Le Wang1,*Weimiao Wu1,*Bin Liu1,2,*Chen Zhu1Yumeng Ding1,3Yi Zhou1,2Weiwei Chen3Lijuan Dai3Xueni Chen3Yuefan Shen3Tingting Pan1Xiaohui Sun2Huizhang Li1Dong Hang3Yingying Mao2 ( )Partha Basu4 ( )Lingbin Du1,5 ( )
Department of Cancer Prevention, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China
Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, Hangzhou 310053, China
Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Early Detection, Prevention & Infections Branch, International Agency for Research on Cancer (WHO), Lyon 69007, France
Zhejiang Key Laboratory of Prevention, Diagnosis and Therapy for Gastrointestinal Cancer, Hangzhou 310022, China

*These authors contributed equally to this work.

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Cancer Biology & Medicine
Pages 1031-1037

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Cite this article:
Wang L, Wu W, Liu B, et al. Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort. Cancer Biology & Medicine, 2026, 23(7): 1031-1037. https://doi.org/10.20892/j.issn.2095-3941.2025.0702

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Received: 28 November 2025
Accepted: 26 February 2026
Published: 24 March 2026
©2026 The Authors.

Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)