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Perspective | Open Access

Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers

Juanjuan Feng1,2,*, Xuanzheng Xiao3,*, Zhengke Lian1, Ao Zhang3, Xiufeng Pang1,4 ( )
Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China
Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China
Shanghai Frontiers Science Center for Drug Target Identification and Delivery, State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China
Chongqing Institute of East China Normal University, Chongqing 401120, China

*These authors contributed equally to this work.

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Cancer Biology & Medicine
Volume 23 Issue 2,
February 2026
Pages 162-168
DOI: 10.20892/j.issn.2095-3941.2025.0612

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Cite this article:
Feng J, Xiao X, Lian Z, et al. Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers. Cancer Biology & Medicine, 2026, 23(2): 162-168. https://doi.org/10.20892/j.issn.2095-3941.2025.0612

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Received: 08 October 2025
Accepted: 05 January 2026
Published: 09 February 2026
©2026 The Authors.

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