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Letter | Open Access

Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT

Qian Li1,2,*, Yaling Wang3,*, Hongfeng Yuan3,*, Qiaomei Cai3,*, Lina Zhao2,3, Li Lin2, Shuang Gao2, Lin Chen2, Zhiying Zhang2, Jing Ma2, Su Liu2, Zeng Cao1, Haifeng Zhao1, Yufei Wang3, Shihui Li3, Pan Lv3, Huihui Zhang3, Guowen Wang4( ), Guang Yang3( ), Xiaodong Zhang3 ( ), Yafei Wang1,2 ( )
Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Department of Blood and Marrow Transplantation, Tianjin Cancer Hospital Airport Hospital, Tianjin 300308, China
State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin’s Clinical Research Center for Cancer, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China

*These authors contributed equally to this work.

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Cancer Biology & Medicine
Volume 23 Issue 2,
February 2026
Pages 247-251
DOI: 10.20892/j.issn.2095-3941.2025.0585

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Li Q, Wang Y, Yuan H, et al. Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT. Cancer Biology & Medicine, 2026, 23(2): 247-251. https://doi.org/10.20892/j.issn.2095-3941.2025.0585

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Received: 10 November 2025
Accepted: 08 January 2026
Published: 27 February 2026
©2026 The Authors.

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