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Letter | Open Access

COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC

Lin Ma1,*Menglin Bai2,*Yao Wang3,*Xueying Zhai1Jinming Yu1 ( )Xiangjiao Meng1 ( )
Department of Radiation Oncology, Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China
Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China
Department of Radiation Oncology, Fujian Medical University, Fuzhou 350001, China

*These authors contributed equally to this work.

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Cancer Biology & Medicine
Pages 1537-1543

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Cite this article:
Ma L, Bai M, Wang Y, et al. COX-2 inhibition synergizes with radioimmunotherapy by promoting TCF1+CD8+ T cell infiltration in NSCLC. Cancer Biology & Medicine, 2025, 22(12): 1537-1543. https://doi.org/10.20892/j.issn.2095-3941.2025.0205

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Received: 26 May 2025
Accepted: 09 September 2025
Published: 22 October 2025
©2025 The Authors.

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