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Review | Open Access

The role of reactive oxygen species in gastric cancer

Yuqi Wang1,2,3,4, Jingli Xu2,3,4, Zhenjie Fu2,3,4, Ruolan Zhang2,3,4, Weiwei Zhu2,3,4, Qianyu Zhao2,3,4, Ping Wang1, Can Hu2,3,4 ( ), Xiangdong Cheng2,3,4 ( )
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
Department of Gastric Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China
Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, Hangzhou 310022, China
Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou 310022, China
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Abstract

Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

Keywords

Gastric cancerreactive oxygen speciesROSantitumor therapynatural productspharmacology

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Cancer Biology & Medicine
Volume 21 Issue 9,
September 2024
Pages 740-753
DOI: 10.20892/j.issn.2095-3941.2024.0182

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Cite this article:
Wang Y, Xu J, Fu Z, et al. The role of reactive oxygen species in gastric cancer. Cancer Biology & Medicine, 2024, 21(9): 740-753. https://doi.org/10.20892/j.issn.2095-3941.2024.0182

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Received: 15 May 2024
Accepted: 12 June 2024
Published: 09 July 2024
©2024 The Authors.

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