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Brain Science Advances 2017, 3(2): 97-103 https://doi.org/10.18679/CN11-6030_R.2017.013
Original Article | Open Access | Issue | Published: 01 June 2017

Is the role of the angiotensin-converting enzyme gene in Alzheimer’s disease independent of hypertension?

Show Author's Information Yuanhan Yang1,2,3,  Shyhjong Wu4,  Chinchun Huang5,  Jongling Fuh6,7( ),  Chingkuan Liu2,3( )
Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Master’s Program in Neurology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan City 333, Taiwan, China
Faculty of Medicine, "National Yang-Ming University Schools of Medicine", Taipei 112, Taiwan, China
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan, China
Keywords:
Alzheimer’s disease, hypertension, angiotensin-converting enzyme, beta-amyloid
Cite this article:
Yang Y, Wu S, Huang C, et al. Is the role of the angiotensin-converting enzyme gene in Alzheimer’s disease independent of hypertension?. Brain Science Advances, 2017, 3(2): 97-103. https://doi.org/10.18679/CN11-6030_R.2017.013
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Abstract Full text About this article
Objective:

Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms are considered biomarkers of late-onset Alzheimer’s disease (AD). However, the results of studies of these polymorphisms have been inconsistent. The ACE protein directly degrades beta-amyloid and thereby slows the progression of AD and its onset. However, it also activates the renin–angiotensin–aldosterone system, which can contribute to hypertension and/or cardiovascular events that increase the risk for developing AD.

Methods:

In this study, we examined the bidirectional association of the ACE gene and AD in patients with AD with and without hypertension.

Results:

Patients who were clinically diagnosed with AD (n = 983) underwent ACE I/D genotyping. The distribution of the ACE I/D genotypes (P = 0.355 for I/I vs. D/D; P = 0.888 for I/D vs. D/D) and I alleles (P = 0.895) did not significantly differ between hypertensive patients with AD and patients with AD without hypertension.

Conclusions:

In contrast to traditional theories, the results of this study suggested that the contribution of the ACE gene to the development of AD was not associated with hypertension and similar cardiovascular effects.


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Abstract
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About this article

Is the role of the angiotensin-converting enzyme gene in Alzheimer’s disease independent of hypertension?

Show Author's information Yuanhan Yang1,2,3, Shyhjong Wu4, Chinchun Huang5, Jongling Fuh6,7( ), Chingkuan Liu2,3( )
Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Master’s Program in Neurology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan City 333, Taiwan, China
Faculty of Medicine, "National Yang-Ming University Schools of Medicine", Taipei 112, Taiwan, China
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan, China

Abstract

Objective:

Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms are considered biomarkers of late-onset Alzheimer’s disease (AD). However, the results of studies of these polymorphisms have been inconsistent. The ACE protein directly degrades beta-amyloid and thereby slows the progression of AD and its onset. However, it also activates the renin–angiotensin–aldosterone system, which can contribute to hypertension and/or cardiovascular events that increase the risk for developing AD.

Methods:

In this study, we examined the bidirectional association of the ACE gene and AD in patients with AD with and without hypertension.

Results:

Patients who were clinically diagnosed with AD (n = 983) underwent ACE I/D genotyping. The distribution of the ACE I/D genotypes (P = 0.355 for I/I vs. D/D; P = 0.888 for I/D vs. D/D) and I alleles (P = 0.895) did not significantly differ between hypertensive patients with AD and patients with AD without hypertension.

Conclusions:

In contrast to traditional theories, the results of this study suggested that the contribution of the ACE gene to the development of AD was not associated with hypertension and similar cardiovascular effects.

Keywords: Alzheimer’s disease, hypertension, angiotensin-converting enzyme, beta-amyloid

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Publication history
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Publication history

Received: 04 March 2017
Revised: 08 April 2017
Accepted: 01 May 2017
Published: 01 June 2017
Issue date: June 2017

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© The authors 2017.

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This article is published with open access at www.TNCjournal.com

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