Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

Peng Li; Qiangyi Zhou; Zhijun Yang; Zhenmin Wang; Shiwei Li; Xingchao Wang; Bo Wang; Fu Zhao; Pinan Liu

doi:10.18679/CN11-6030_R.2016.024

Brain Science Advances 2016, 2(3): 155-164 https://doi.org/10.18679/CN11-6030_R.2016.024

Original Article |

Open Access | Issue | Published: 01 September 2016

Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

Show Author's Information Hide Author's Information Peng Li^¹, Qiangyi Zhou^¹, Zhijun Yang^¹, Zhenmin Wang^¹, Shiwei Li^¹, Xingchao Wang^¹, Bo Wang^¹, Fu Zhao^², Pinan Liu^{¹^,²}(

)

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

2Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, China

Keywords:

literature review, clinical features, prognostic factors, intracranial malignant fibrous histiocytoma

Cite this article:

Li P, Zhou Q, Yang Z, et al. Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review. Brain Science Advances, 2016, 2(3): 155-164. https://doi.org/10.18679/CN11-6030_R.2016.024

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Abstract

Objective:

Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors.

Methods:

Eight patients with pathologically confirmed primary intracranial MFH were retrospectively reviewed. We searched PubMed for relevant articles with the term "intracranial malignant fibrous histiocytoma" .

Results:

Of the 8 patients, 4 were men and 4 were women. Three patients had received previous radiotherapy. The age of the patients ranged from 19 to 69 years, with a median age of 48 years. Most tumors could be totally resected; and only 1 tumor was subtotally resected. Six patients received postoperative radiotherapy and 3 patients received postoperative chemotherapy. Most patients died within the first year after surgery; and only 1 patient was still alive on the date of the last follow-up. We reviewed the literature and included a total of 46 patients in the Kaplan-Meier survival analysis. Young patients (less than 30 years old) seemed to have a better prognosis and survival rate than older patients (more than 30 years old) (log-rank test, P = 0.008). However, sex (P = 0.675), extent of resection (P = 0.934), postoperative radiotherapy (P = 0.592), and postoperative chemotherapy (P = 0.424) did not affect patient prognosis.

Conclusions:

The prognosis of MFH is usually poor, and most patients die within the first year after surgery. Younger MFH patients (less than 30 years old) seem to have a better prognosis and improved survival compared to older patients.

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Clinical features and prognostic factors of primary intracranial malignant fibrous histiocytoma: A report of 8 cases and a literature review

Show Author's information Hide Author's Information Peng Li^¹, Qiangyi Zhou^¹, Zhijun Yang^¹, Zhenmin Wang^¹, Shiwei Li^¹, Xingchao Wang^¹, Bo Wang^¹, Fu Zhao^², Pinan Liu^{¹^,²}(

)

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

2Department of Neural Reconstruction, Beijing Neurosurgery Institute, Capital Medical University, Beijing 100050, China

Abstract

Objective:

Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors.

Methods:

Results:

Conclusions:

Keywords: literature review, clinical features, prognostic factors, intracranial malignant fibrous histiocytoma

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Received: 10 July 2016

Revised: 10 July 2016

Accepted: 20 August 2016

Published: 01 September 2016

Issue date: September 2016

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This article is published with open access at www.TNCjournal.com