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Clinical Research | Open Access

Assessment of iris volume in glaucoma patients with type 2 diabetes mellitus by AS-OCT

Ying Su1,2,3,4, Qing-Shu Ge2,3,4, Zong-Yi Li2,3,4, Qian-Wen Bu2,3,4, Die Hu2,3,4, Long-Fang Zhou2,3,4, Xiao-Jing Pan2,3,4( )
School of Clinical Medicine, Weifang Medical University, Weifang 261021, Shandong Province, China
Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao 266071, Shandong Province, China
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, Shandong Province, China
School of Ophthalmology, Shandong First Medical University, Qingdao 266071, Shandong Province, China

Co-first authors: Ying Su and Qing-Shu Ge

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Abstract

AIM

To examine the change of iris volume measured by CASIA2 anterior segment optical coherence tomography (AS-OCT) in glaucoma patients with or without type 2 diabetes mellitus (T2DM) and explore if there is a correlation between hemoglobin A1c (HbA1c) level and iris volume.

METHODS

In a cross-sectional study, 72 patients (115 eyes) were divided into two groups: primary open angle glaucoma (POAG) group (55 eyes) and primary angle-closure glaucoma (PACG) group (60 eyes). Patients in each group were separately classified into patients with or without T2DM. Iris volume and glycosylated HbA1c level were measured and analyzed.

RESULTS

In the PACG group, diabetic patients’ iris volume was significantly lower than those of non-diabetics (P=0.02), and there was a significant correlation between iris volume and HbA1c level in the PACG group (r=-0.26, P=0.04). However, diabetic POAG patients’ iris volume was noticeably higher than those of non-diabetics (P=0.01), and there was a significant correlation between HbA1c level and iris volume (r=0.32, P=0.02).

CONCLUSION

Diabetes mellitus impact iris volume size, as seen by increased iris volume in the POAG group and decreased iris volume in the PACG group. In addition, iris volume is significantly correlated with HbA1c level in glaucoma patients. These findings imply that T2DM may compromise iris ultrastructure in glaucoma patients.

Keywords

glaucomadiabetes mellitusiris volumeglycosylated hemoglobinoptical coherence tomography

References

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International Journal of Ophthalmology
Volume 16 Issue 5,
May 2023
Pages 743-747
DOI: 10.18240/ijo.2023.05.11

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Cite this article:
Su Y, Ge Q-S, Li Z-Y, et al. Assessment of iris volume in glaucoma patients with type 2 diabetes mellitus by AS-OCT. International Journal of Ophthalmology, 2023, 16(5): 743-747. https://doi.org/10.18240/ijo.2023.05.11

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Received: 16 February 2023
Accepted: 06 March 2023
Published: 18 May 2023
© 2023 International Journal of Ophthalmology Press

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).