Research Progress on Detection Technology of Illegal Additions in Chinese Patent Medicines and Health Care Products

In recent years, Chinese patent medicines and health care products have become more popular, but some businessmen have added illegal additions in them for profit. At present, there are many kinds of illegal additions. The objects of this study mainly include seven categories: medicines for regulating blood pressure, medicines for blood sugar regulation, medicines for blood lipid regulation and so on. These drugs may lead to a series of problems in cardiovascular, hepatic/renal function, which can be life-threatening in serious cases. In order to protect public health and rights, China has issued many standards and relevant guidelines. The main detection techniques are: immunoassay, spectroscopy, chromatography and the combination of various technologies and real-time direct analysis mass spectrometry. This paper summarized the categories of illegal additions in recent years, the commonly used sample pretreatment technology and the corresponding detection technology, and briefly introduced the characteristics of each technology. Finally, an outlook is given about the management of new illicitly added chemicals, the direction of development on related detection technologies, and the measures to deal with new illicitly added chemicals.