Theoretical Basis and Research Progress of Hair Matrix Reference Material in the Field of Forensic Toxicology

Hair matrix reference material is a class of reference material in which the target substance is combined with the biological matrix of hair and the concentration of the target substance is determined. Hair matrix reference material has a higher consistency with the real case samples involved in the feld of forensic toxicology, reducing errors in calibration and validation by using this material during sample pre-treatment and instrument detection processes, thereby enhancing the accuracy and reproducibility of detection data, and its application has a positive effect on improving the testing ability of laboratories, advancing scientific and technological progress in the field of forensic toxicology, and enhancing judicial impartiality. This paper focuses on the hair matrix samples which are commonly analyzed in forensic toxicology, specifically addresses the structure of hair, the mechanism through which drug are incorporated into the hair, main preparation methods of hair matrix reference material, and provided a comprehensive evaluation of theoretical basis and development status of hair matrix reference materials for analysis in forensic toxicology. It is intended to serve as a reference for the development and application of hair matrix reference material.