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Publishing Language: Chinese

Causality between ischemic stroke and epilepsy based on Mendelian randomization

Yun SHU1,3, Qing YUAN1, Zhifeng WU2, Chunqing ZHANG3( )
Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006
Department of Pediatrics, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China
Department of Neurosurgery, PLA Center for Epilepsy Diagnosis and Treatment, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China
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Abstract

Objective

To explore the causal relationship between ischemic stroke and different types of epilepsy so as to provide genetic evidence for the risk of epilepsy after ischemic stroke.

Methods

Based on the summary data of genome-wide association study, Mendelian randomization (MR) analysis was performed with MR-Egger regression, weighted median and inverse-variance weighting. Sensitivity analysis was conducted by using MR-Egger regression test, MR-PRESSO test and leave-one-out method.

Results

Two-sample MR analysis showed that there was a causal relationship between ischemic stroke and the risk of epilepsy (OR=1.10, P=0.036) and generalized epilepsy (OR=1.25, P=0.001), but no such relationship was observed with the risk of focal epilepsy (OR=1.06, P=0.360). In addition, diastolic blood pressure (OR=1.12, P=0.002) and BMI (OR=1.08, P=0.015) also had a causal relationship with the risk of epilepsy. After adjusting confounding factors, multivariate MR analysis revealed that only ischemic stroke (OR=1.18, P=3.770×10-6) and epilepsy risk had a causal relationship.

Conclusion

There is a causal relationship between ischemic stroke and the risk of generalized epilepsy, which can be used to stratify the risk of post-stroke epilepsy.

Keywords

ischemic strokeepilepsyMendelian randomizationcausal relationship
CLC number: R192.6;R195.1;R473.1 Document code: A

References

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Journal of Army Medical University
Volume 46 Issue 20,
October 2024
Pages 2276-2283
DOI: 10.16016/j.2097-0927.202403006

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Cite this article:
SHU Y, YUAN Q, WU Z, et al. Causality between ischemic stroke and epilepsy based on Mendelian randomization. Journal of Army Medical University, 2024, 46(20): 2276-2283. https://doi.org/10.16016/j.2097-0927.202403006

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Received: 03 March 2024
Revised: 19 May 2024
Published: 30 October 2024
© 2024 Journal of Army Medical University