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Publishing Language: Chinese

Catalpol protects hepatopulmonary syndrome rats against liver and lung injury

Ziyang ZENG1, Yuhao LEI1, Xianfeng WU1, Ailin SONG2, Chunyong YANG1, Zhiyong YANG1, Yujie LI1, Bin YI1( )
Department of Anesthesiology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038
Department of Anesthesiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China
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Abstract

Objective

To explore the protective effect of catalpol by enhancing TGR5 expression and reducing bile acid (BAs) level against liver and lung injury in rats with common bile duct ligation (CBDL).

Methods

Fifty male rats were randomly divided into sham-operation group (n=10), CBDL group (n=20) and catalpol group (n=20). The survival rate, arterial partial pressure of oxygen (PO2) and alveolar and arterial PO2 gradient difference [P(A-a)O2], liver function, and pathological changes in the liver and lungs. The relationship between bile acid level and TGR5 was analyzed.

Results

Catalpol ameliorated liver function damage, improved survival rate and hypoxemia induced by CBDL. It also reduced angiogenesis in the liver and lung. Meanwhile, catalpol mitigated lung injury caused by excessive BAs levels through enhancing TGR5 expression and reducing FXR expression.

Conclusion

The protective effects of catalpol on CBDL lung injury caused by excessive BAs levels through enhancing TGR5 expression and reducing FXR expression.

Keywords

hepatopulmonary syndromecatalpolTRGR5bile acids
CLC number: R282.71;R285.5;R575 Document code: A

References

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Journal of Army Medical University
Volume 46 Issue 6,
March 2024
Pages 587-596
DOI: 10.16016/j.2097-0927.202312145

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Cite this article:
ZENG Z, LEI Y, WU X, et al. Catalpol protects hepatopulmonary syndrome rats against liver and lung injury. Journal of Army Medical University, 2024, 46(6): 587-596. https://doi.org/10.16016/j.2097-0927.202312145

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Received: 30 December 2023
Revised: 27 January 2024
Published: 30 March 2024
© 2024 Journal of Army Medical University