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Publishing Language: Chinese

Research Progress on Depressive Symptoms in the Elderly with Cognitive Frailty

Yang LI1, Donglei SHI2, Yonghua CAI2, Jiazhen LIU1, Xiaopeng HUO2, Xiaoxing LAI1( )
The First Ward of Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Nursing Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
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Abstract

With the accelerating global trend of population aging, health issues among the elderly have garnered increasing attention. Cognitive frailty and depressive symptoms, are common health concerns in this population, significantly impacting mental health and quality of life, and are closely linked to a range of adverse health outcomes. This article provides an updated review of recent advances in research on depressive symptoms in the elderly with cognitive frailty, focusing on clinical epidemiology, shared pathophysiological mechanisms, and key influencing factors. The aim is to offer robust theoretical foundations and practical guidance for the optimization of elderly health services and policy development, and ultimately achieve the goals of healthy aging and improvement of quality of life for the elderly.

CLC number: R592;R749.4 Document code: A Article ID: 1674-9081(2026)05-1429-08

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Medical Journal of Peking Union Medical College Hospital
Pages 1429-1436

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Cite this article:
LI Y, SHI D, CAI Y, et al. Research Progress on Depressive Symptoms in the Elderly with Cognitive Frailty. Medical Journal of Peking Union Medical College Hospital, 2026, 17(5): 1429-1436. https://doi.org/10.12290/xhyxzz.2025-0341

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Received: 11 April 2025
Accepted: 29 May 2025
Published: 15 March 2026
© 2026 Medical Journal of Peking Union Medical College Hospital