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Publishing Language: Chinese

Research Progress on Animal Models of Systemic Sclerosis with Microvascular Involvement

Haochen HUANG1, Lingling ZHANG2, Dong XU1( )
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Rheumatology and Clinical Immunology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
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Abstract

The early angiopathy of systemic sclerosis (SSc) is a key hub connecting inflammation and fibrosis. The animal models that simulate the pathological characteristics of SSc are of great significance to study the etiology, pathogenesis and treatment of SSc with vascular involvement. This review of the characteristics of different animal models of SSc with vascular involvement provides a reference for relevant researchers to select appropriate models in the process of exploring the pathogenesis of SSc with vascular involvement.

Keywords

systemic sclerosismicrovascular involvementanimal model
CLC number: R593.25; R543.7 Document code: A Article ID: 1674-9081(2026)03-0834-08

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Medical Journal of Peking Union Medical College Hospital
Volume 17 Issue 3,
May 2026
Pages 834-841
DOI: 10.12290/xhyxzz.2025-0164

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Cite this article:
HUANG H, ZHANG L, XU D. Research Progress on Animal Models of Systemic Sclerosis with Microvascular Involvement. Medical Journal of Peking Union Medical College Hospital, 2026, 17(3): 834-841. https://doi.org/10.12290/xhyxzz.2025-0164

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Received: 28 February 2025
Accepted: 13 May 2025
Published: 12 January 2026
© 2026 Medical Journal of Peking Union Medical College Hospital