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Publishing Language: Chinese

Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases

Yongtai ZHOU1,2, Zhenyu YANG1,2, Yan LI1,2, Jiajing WU1,2, Bo ZHAO2( )
The First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
Department of Neurology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, China
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Abstract

Lipocalin-2 (LCN2), a member of the human lipocalin family, has been demonstrated to be closely associated with diabetes, cardiovascular diseases, and renal disorders. Recent studies have indicated that LCN2 plays a significant regulatory role in the pathogenesis and progression of various neurological diseases by mediating pathways such as inflammation, oxidative stress, and ferroptosis. This article reviews the research advancements on the mechanism of LCN2 in neurological disorders, including cerebrovascular diseases, cognitive impairment disorders, Parkinson's disease, depression, and anxiety disorders, aiming to enhance clinical understanding.

Keywords

lipocalin-2cerebrovascular diseasecognitive impairment diseasesneurodegenerative diseaseanxiety disordersdepression
CLC number: R742;R364 Document code: A Article ID: 1674-9081(2025)02-0330-08

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Medical Journal of Peking Union Medical College Hospital
Volume 16 Issue 2,
March 2025
Pages 330-337
DOI: 10.12290/xhyxzz.2025-0028

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Cite this article:
ZHOU Y, YANG Z, LI Y, et al. Research Progress on the Mechanism of Lipocalin-2 in Neurological Diseases. Medical Journal of Peking Union Medical College Hospital, 2025, 16(2): 330-337. https://doi.org/10.12290/xhyxzz.2025-0028

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Received: 08 January 2025
Accepted: 28 February 2025
Published: 06 March 2025
© 2025 Medical Journal of Peking Union Medical College Hospital