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Review | Publishing Language: Chinese

Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori

Zhencan SUN1,2, Jukun ZHOU1,2, Yunpeng XU1, Jun WANG2,3, Ya ZHENG2,4, Yuping WANG2,4, Rui JI2,3,4( )
The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, China
Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China
Digestive Endoscopy Center, the First Hospital of Lanzhou University, Lanzhou 730000, China
Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China
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Abstract

Helicobacter pylori (Hp) is a unipolar, microaerobic, multiflagellar, spiral-shaped Gram-negative bacterium that survives and colonizes human gastric mucosa. As a classⅠcarcinogen associated with gastric cancer, long-term stimulation of gastric mucosa by Hp can cause atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It has been reported that Hp can cause epithelial-mesenchymal transition (EMT) in gastric epithelial cells, thereby inducing gastric cancer. We review the mechanism of Hp-induced EMT in gastric epithelial cells, in order to provide new insights for early diagnosis and targeted therapy of gastric cancer.

Keywords

Helicobacter pyloriepithelial-mesenchymal transitiongastric cancercytotoxin-associated gene Amesenchymal stem cells
CLC number: R735.2; R573; R516 Document code: A Article ID: 1674-9081(2024)01-0160-06

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Medical Journal of Peking Union Medical College Hospital
Volume 15 Issue 1,
January 2024
Pages 160-165
DOI: 10.12290/xhyxzz.2023-0341

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SUN Z, ZHOU J, XU Y, et al. Mechanism of Epithelial-mesenchymal Transition Leading to Gastric Cancer Induced by Helicobacter pylori. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 160-165. https://doi.org/10.12290/xhyxzz.2023-0341

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Received: 23 July 2023
Accepted: 08 September 2023
Published: 30 January 2024
© 2024 Medical Journal of Peking Union Medical College Hospital