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Publishing Language: Chinese

The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms

Biqing HUANG1,2,3Lanjuan LI1,3( )
Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences & Peking Union Medical College, Hangzhou 310003, China
NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102600, China
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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Abstract

Vaccine is the most effective method to prevent the spread of communicable diseases, but the immune response it induces varies significantly among individuals and populations in different regions. Recent studies have shown that the composition and function of the gut microbiota play a key role in the immune response following vaccination. This article aims to explain the differences in gut microbiota among different vaccinated populations and animals, discuss how the gut microbiota affects the immune efficacy of the vaccine, and summarize strategies for targeting the gut microbiota to improve vaccine efficacy.

CLC number: R392;R186;S852.5+2 Document code: A Article ID: 1674-9081(2023)05-0939-06

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Medical Journal of Peking Union Medical College Hospital
Pages 939-944

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Cite this article:
HUANG B, LI L. The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 939-944. https://doi.org/10.12290/xhyxzz.2023-0173

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Received: 03 April 2023
Accepted: 29 May 2023
Published: 01 June 2023
© 2024 Medical Journal of Peking Union Medical College Hospital