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Publishing Language: Chinese

Design and Analysis of the Operation Effect of the Safety Management System for Antitumor Drugs

Wenjuan SUN1, Yuzhen ZOU1, Fan ZHANG1, Lu ZHANG2, Lin ZHAO3, Chunmei BAI3, Feng ZHANG4, Yan XU5, Feng MAO6, Jing LI7, Yu GU8, Xinrong FAN9, Mengzhao WANG5, Daobin ZHOU2, Zhanjie ZHANG10, Bin ZHAO1( ), Xiaoli DU1, Bo ZHANG1, Xueqin SUN11, Xiao LONG12, Qing CHANG10, Bingshui HU11, Hui PAN10, Wenming WU13,14
Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Information Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Medical Affairs, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Administration Office of Western Branch of the Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of Administrative Office, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
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Abstract

Objective

To design a safety management system for antitumor drugs, which can intercept or warn the overdose of medical orders from the prescription source, and ensure the safety of clinical application of antitumor drugs.

Methods

The threshold of interception and warning strategy of 88 kinds of antitumor drugs were developed, and the safety management system of antitumor drugs was established to intercept or warn the overdose orders. The interception and warning data from January 2021 to June 2021 in the safety management system of antitumor drugs were extracted and analyzed.

Results

A total of 665 medical orders were intercepted or warned by the safety management system of antitumor drugs, and the majority of the intercepted or warned drugs were oral tablets(74.29%). The intercepted orders were 642 (96.54%), and the warned orders were 23(3.46%). Among the intercepted medical orders, frequency error (64.22%) has the highest proportion, followed by route error (11.73%) and dose error (9.92%). A total of 564 medical orders were intercepted, involving 28 kinds of antitumor drugs. Methotrexate tablets ranked first in overdose quantity, with an average of seven times. Pemetrexed ranked first in overdose multiples, with an average overdose of 1000 times. 78 medical orders were intercepted for over pathway, involving 5 kinds of antitumor drugs.

Conclusion

The safety management system of antitumor drugs can eliminate the error of overdose in prescription and guarantee the safety of antitumor drugs.

Keywords

antitumor drugssafety management systemover dosemedication safety
CLC number: R979.1;R730.53 Document code: A Article ID: 1674-9081(2022)03-0461-07

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Medical Journal of Peking Union Medical College Hospital
Volume 13 Issue 3,
May 2022
Pages 461-467
DOI: 10.12290/xhyxzz.2021-0704

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SUN W, ZOU Y, ZHANG F, et al. Design and Analysis of the Operation Effect of the Safety Management System for Antitumor Drugs. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 461-467. https://doi.org/10.12290/xhyxzz.2021-0704

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Received: 21 October 2021
Accepted: 18 January 2022
Published: 05 March 2022
© 2024 Medical Journal of Peking Union Medical College Hospital