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Clinical Study | Publishing Language: Chinese | Open Access

Systematic review of clinical effects of enamel matrix derivative as adjunctive therapy for gingival recession

Ruonan XU1,2, Yiru WEI1,2, Xintong YANG1, Awuti GULINUER1,2( )
Periodontal and Mucosal Department, the First Affiliated Hospital of Xinjiang Medical University (the Affiliated Stomatology Hospital of Xinjiang Medical University), Urumqi 830054, China
Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region, Urumqi 830011, China
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Abstract

Objective

To evaluate the clinical effect of enamel matrix derivative(EMD) assisted with connective tissue graft(CTG) in the treatment of gingival recession.

Methods

Search The Cochrane Library, PubMed, EMbase, Web of Science, Wanfang Public Database, VIP database and CNKI to search for randomized controlled trials of EMD in the treatment of gingival recession. The search period is from the establishment of the databases to October 3, 2022. The test group was treated with EMD+CTG, while the control group was treated with CTG alone. Meta-analyses were performed using Review Manager 5.4.1 and Stat12.0.

Results

Meta analysis results showed that only 12 months after treatment, there was a statistically significant difference in the PD and CAL outcome indicators between the EMD assisted treatment group and the control group [MDPD=-0.10, 95% CI (-0.19, -0.01), P = 0.03], [MDCAL=-0.38, 95% CI (-0.71, -0.04), P = 0.03]. There was no significant difference between the test group and the control group in other indicators.

Conclusion

EMD assisted CTG in the treatment of gingival recession may be beneficial to the reduction of PD and CAL.

Keywords

enamel matrix derivativeconnective tissue graftgingival recessionkeratinized tissue widthprobing depthclinical attachment lossrandomized controlled trialmeta analysissystematic review
CLC number: R78 Document code: A Article ID: 2096-1456(2023)04-0261-06

References

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 31 Issue 4,
April 2023
Pages 261-266
DOI: 10.12016/j.issn.2096-1456.2023.04.006

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Cite this article:
XU R, WEI Y, YANG X, et al. Systematic review of clinical effects of enamel matrix derivative as adjunctive therapy for gingival recession. Journal of Prevention and Treatment for Stomatological Diseases, 2023, 31(4): 261-266. https://doi.org/10.12016/j.issn.2096-1456.2023.04.006

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Received: 17 October 2022
Revised: 16 November 2022
Published: 20 April 2023
© 2023 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.