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Basic Study | Publishing Language: Chinese | Open Access

Significance of phosphoinositol metabolism by DNA methylation may contribute in oral leukoplakia carcinogenesis

Guangchao WANG, Lijun LIU, Weiwen JIANG( )
Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China
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Abstract

Objective

To study the role of DNA methylation in oral leukoplakia carcinogenesis.

 Methods

DNA methylation was detected in forty cases of oral squamous cell carcinoma (OSCC), twenty-eight cases of oral leukoplakia (OLK) and forty cases of healthy oral mucosa. Download the expression profile data of OSCC, OLK and healthy oral mucosa from Gene Expression Omnibus (GEO) database. DNA methylation data and expression profile data were compared for repeatability, DNA methylation data for difference analysis and corresponding expression profile data for IPA pathway analysis.

 Results

The data analysis showed that DNA methylation had greater flexibility and instability. Ingenuity Pathway Analysis (IPA) analysis showed that genes related to OLK differential methylation sites were mainly concentrated in the process of cell movement and differentiation. Genes related to differential methylation sites of OSCC are mainly enriched in cell proliferation, migration, oxidation regulation, and anti-apoptosis processes. The genes associated with OLK and OSCC differential methylation sites are co-enriched in phosphoinositol metabolism and phospholipase C signaling pathway.

 Conclusion

DNA methylation is involved in the formation of oral squamous cell carcinoma, and the activation of phosphoinositol metabolism may promote oral leukinoma.

Keywords

oral leukoplakiaoral squamous cell carcinomaepigeneticsDNA methylationinositolphosphoinositolmetabolismphospholipase Cinflammationcalcium signal
CLC number: R78 Document code: A Article ID: 2096-1456(2021)10-0677-07

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 29 Issue 10,
October 2021
Pages 677-683
DOI: 10.12016/j.issn.2096-1456.2021.10.005

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Cite this article:
WANG G, LIU L, JIANG W. Significance of phosphoinositol metabolism by DNA methylation may contribute in oral leukoplakia carcinogenesis. Journal of Prevention and Treatment for Stomatological Diseases, 2021, 29(10): 677-683. https://doi.org/10.12016/j.issn.2096-1456.2021.10.005

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Received: 30 January 2021
Revised: 01 May 2021
Published: 20 October 2021
© 2021 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.