Clinical effect of platelet-rich fibrin combined with bone substitute in alveolar ridge preservation

To study the clinical outcomes of implanting platelet rich fibrinogen (PRF) mixed with Bio-Oss^® in the extraction socket for alveolar ridge preservation and to provide evidence for clinical application.

Thirty-six patients who underwent alveolar ridge preservation were enrolled. Thirty-six extraction sites were divided into two groups: PRF mixed with Bio-Oss^® group (test group) and Bio-Oss^® alone (control group). Bone dimensional changes in height and width were measured by CBCT before and 6 months after surgery, and early soft tissue healing and postoperative pain sensation were evaluated clinically 1 week after surgery.

There was no significant difference in the alveolar bone height (-1.48 ± 0.40) mm between the test group and the control group. The difference in the alveolar bone width between the test group (-1.09 ± 0.42) mm and the control group (-1.35 ± 0.22) mm was statistically significant (z＝-2.63, P＝0.01). The postoperative pain score of the test group was 2.39 ± 1.20, and that of the control group was 3.39 ± 1.65, the difference was statistically significant (t＝-2.083, P＝0.045). There was no significant difference in soft tissue healing between the test group and the control group.

The use of PRF mixed with Bio-Oss^® in the alveolar ridge preservation procedure can reduce alveolar bone absorption and postoperative pain.