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Publishing Language: Chinese | Open Access

Study of the therapeutic effect of oral propranolol combined with topical timolol maleate in the treatment of mixed maxillofacial hemangioma in infants

Jiapeng LI1, Jufeng CHEN1, Guorun ZHANG1, Dan XIAN1, Jin LI1, Lei WANG1, Guoyi ZHANG2( )
Stomatological Center, Foshan First People′s Hospital, Foshan 528000, China
Nasopharyngeal Radiotherapy Department 2, Foshan First People′s Hospital, Foshan 528000, China
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Abstract

Objective

To observe the treatment effect of oral propranolol combined with topical timolol maleate for infantile maxillofacial mixed hemangioma and provide evidence for clinical treatment.

Methods

Ninety-seven cases of infantile maxillofacial mixed hemangioma were enrolled. The cases were randomly divided into A and B groups: 50 cases in group A were treated with oral propranolol combined with topical timolol maleate, and 47 cases in group B were treated with oral propranolol only. The changes in the color, volume, and texture of the tumors were recorded before and after treatment, and color ultrasonography of the lesion area was performed. The follow-up time was 1-12 months. The differences in the curative effect, effective time and adverse reaction between the two groups were compared.

Results

The effective rate of group A was 92.0% (46/50) and that of group B was 74.5% (35/47), with a statistical significance (P < 0.05). The mean time of treatment in group A was 4.2 months and that in group B was 5.5 months. Compared with group B, the treatment time of group B was shorter (t = 3.211, P < 0.05), and no serious adverse reactions occurred in both groups.

Conclusion

Oral propranolol combined with topical timolol maleate is effective in the treatment of mixed hemangioma of the maxillofacial region in infants.

Keywords

mixed hemangiomainfantpropranololtimolol maleatetopical therapycurative effectadverse reactions
CLC number: R782 Document code: A Article ID: 2096-1456(2019)11-0718-05

References

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 27 Issue 11,
November 2019
Pages 718-722
DOI: 10.12016/j.issn.2096-1456.2019.11.006

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LI J, CHEN J, ZHANG G, et al. Study of the therapeutic effect of oral propranolol combined with topical timolol maleate in the treatment of mixed maxillofacial hemangioma in infants. Journal of Prevention and Treatment for Stomatological Diseases, 2019, 27(11): 718-722. https://doi.org/10.12016/j.issn.2096-1456.2019.11.006

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Received: 04 April 2019
Revised: 16 May 2019
Published: 20 November 2019
© 2019 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.