Research progress on osteoinductive properties of bone substitute materials

Bone graft material is not only a simple scaffold frame, but also a material with the potential to induce cells grow and differentiate into osteoblasts. The material with excellent bone induction properties can accelerate the healing of bone defect, thus repair the large area of bone defect successfully. Currently, plenty of researches regarding the bone induction in bone graft material have been reported, how to maximize the material osteoinductive potential, and to take advantage of these biological materials to produce the next generation of innovative biological material, is the current concerns. In this paper, a review is made on the bone induction properties of several kinds of bone substitutes.