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Basic Study | Publishing Language: Chinese | Open Access

The osteoplastic effect of Y500R coral hydroxyapatite composite grafts with fluoride on the rabbit skull

Yi GUO1, Lei ZHOU2( ), Jian-ya XIE3
Department of Stomatology, Southern Medical University Affiliated Nanhai Hospital, Foshan 528200, China
Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China
Hospital of Traditional Chinese Medicine, FoShan 528000, China
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Abstract

Objective

To explore the effect and changes in osteogenesis efficacy of CHA (Coral hydroxyapatite) composite grafts with fluoride in guided bone augmentation on rabbit skull.

Methods

Twenty-four rabbits were studied. Y500R CHA composite grafts contained fluoride and titanium cylinders were prepared. Two titanium cylinders on the test group's rabbit skull were filled with composite grafts contain fluoride and non-fluoride grafts were filled in the control group. Cyclomycin and calcein were injected, After 2, 4 and 6 weeks, the animals were sacrificed to obtain ground sections for histology and histomorphometry. The general observation and area of highly fluorescent band of new bone formation was measured after sample treatment.

Results

Significantly more neogenesis bone was augmented in the test groups than the control group. The osteoplastic effect in the test group more athletic. The experimental data had statistical significance (F = 6.36, P = 0.0193).

Conclusion

Low concentration (1.0 × 10-7 mol/L ~ 5.0 × 10-5 mol/L) fluoride can promote bone formation effectively.

Keywords

FluorideCoral hydroxyapatiteBone substituteOsteogenesis effectItanium cylinders barrier
CLC number: R783.4 Document code: A Article ID: 2096-1456(2016)12-695-06

References

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 24 Issue 12,
December 2016
Pages 695-700
DOI: 10.12016/j.issn.2096-1456.2016.12.003

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Cite this article:
GUO Y, ZHOU L, XIE J-y. The osteoplastic effect of Y500R coral hydroxyapatite composite grafts with fluoride on the rabbit skull. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(12): 695-700. https://doi.org/10.12016/j.issn.2096-1456.2016.12.003

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Received: 11 March 2016
Revised: 06 May 2016
Published: 20 December 2016
© 2016 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.