Study on animal model of early osteogenesis on the surface of titanium implant

To study the animal model suitable for the observation of early osteogenesis on the surface of titanium implant.

Modify implants mode which the outer thread of the implant next to the osteotomy bone wall while the inter thread keep a certain distance to osteotomy bone wall was adopted in the 1-year-old male Beagle dogs. After extraction of all mandibular premolars and first molar bilaterally in the 4 dogs, 20 implants replaced the position. All sections were stained for histological analysis.

The surgical wound in the 4 dogs healed by first intention. The titanium implants have good stability. The formation of the new bone, which include the contact osteogenesis and distance osteogenesis, was observed as it progressed not only in the surface of the osteotomy bone wall but also in the surface of the implants.

The established animal model is suitable for the observation of both early osteogenesis in implant and the influences of implant surface properties to the early osteogenesis.