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Basic Study | Publishing Language: Chinese | Open Access

The influence of artesunate on T-bet /GATA-3 equilibrium of peripheral blood in oral lichen planus

Li-fang LIU1, Yu-lei HUANG( ), Xue-lian DENG, Chun-mei YU
Department of stomatology, the First People's Hospital of Foshan City, Foshan 528000, China
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Abstract

Objective

To explore influence of artesunate on T-bet / GATA-3 equilibrium of peripheral blood in oral lichen planus.

Methods

18 OLP patients were selected, and peripheral blood mononuclear cells (PBMCs) were isolated by density gradient centrifugation. The cells were cultured and treated with different concentrations (0, 1, 100 μmol/L) of artesunate. Reverse transcription polymerase chain reaction (RT-PCR) and Western blot were applied to detect the T-bet and GATA-3 mRNA and protein expression respectively.

Results

The T-bet/GATA-3 mRNA and protein expressions in groups treated with artesunate (1 μmol/L & 100 μmol/L) were higher than that of control group (treated without artesunate)(P ＜ 0. 05), and the expressions were improved significantly in high concentration group (100 μmol/L) compared with low concentration group (1 μmol/L)(P ＜ 0. 05).

Conclusion

Artesunate can regulate the T-bet/GATA-3 balance in OLP effectively.

Keywords

ArtesunateOral lichen planusT-betGATA-3Reverse transcription-PCR
CLC number: R781.5 Document code: A Article ID: 2096-1456(2016)04-222-04

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 24 Issue 4,
April 2016
Pages 222-225
DOI: 10.12016/j.issn.2096-1456.2016.04.005

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LIU L-f, HUANG Y-l, DENG X-l, et al. The influence of artesunate on T-bet /GATA-3 equilibrium of peripheral blood in oral lichen planus. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(4): 222-225. https://doi.org/10.12016/j.issn.2096-1456.2016.04.005

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Received: 21 May 2015
Revised: 06 December 2015
Published: 20 April 2016
© 2016 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.