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Basic Study | Publishing Language: Chinese | Open Access

Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning

Zeng-wen YUE1, Jin-zhong LIU( ), Bao-yu ZHU, Zheng-guang CHEN
the Fourth Affiliated Hospital of Zhengzhou University. Zhengzhou 450052, China
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Abstract

Objective

To investigate the expression of TKTL1 (transketolase-like protein 1) gene and its correlation with clinicopathological characteristics and prognosis of human tongue squamous cell carcinoma.

Methods

Immunohistochemistry was used to detect the TKTL1 protein levels in 45 human tongue cancer specimens and matched normal tissues.

Results

The positive expression ratio of TKTL1 protein in tongue squamous carcinoma tissues (68. 89%) was significantly higher than that in normal tissues (15. 56%), and the difference was statistically significant (χ2 = 26. 235, P ＜0. 01). The high level of TKTL1 was not statistically correlated with age, gender and tumor differentiated degree (P ＞0. 05), however it was associated with TNM staging and lymph node metastasis (P ＜ 0. 05) notably. Mantel-Cox demonstrated the survival time of patients with high TKTL1 expression was significantly lower than those with low TKTL1 expressions.

Conclusion

It suggests a high TKTL1 expression may be tightly related to the occurrence, development, progression and prognosis of human tongue squamous cell carcinoma.

Keywords

Transketolase-like protein 1TongueSquamous cell carcinomaClinicopathological characteristicsPrognosis
CLC number: R739.86 Document code: A Article ID: 2096-1456(2016)03-150-04

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 24 Issue 3,
March 2016
Pages 150-153
DOI: 10.12016/j.issn.2096-1456.2016.03.005

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Cite this article:
YUE Z-w, LIU J-z, ZHU B-y, et al. Expression of transketolase-like protein 1 in human tongue carcinoma and its meaning. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(3): 150-153. https://doi.org/10.12016/j.issn.2096-1456.2016.03.005

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Received: 06 November 2015
Revised: 24 November 2025
Published: 20 March 2016
© 2016 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.