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Journal of Geriatric Cardiology 2022, 19(8): 594-602 https://doi.org/10.11909/j.issn.1671-5411.2022.08.002
Research Article | Open Access | Issue | Published: 28 August 2022

Relationship between arterial stiffness and cognitive function in outpatients with dementia and mild cognitive impairment compared with community residents without dementia

Show Author's Information Ai Hirasawa1,  Kumiko Nagai2,  Taiki Miyazawa3,  Hitomi Koshiba2,  Mami Tamada2,  Shigeki Shibata2( ),  Koichi Kozaki2
Department of Health and Welfare, Faculty of Health Sciences, Kyorin University, Tokyo, Japan
Department of Geriatric Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan
Department of Health and Sports Science, Faculty of Wellness, Shigakkan University, Aichi, Japan
Cite this article:
Hirasawa A, Nagai K, Miyazawa T, et al. Relationship between arterial stiffness and cognitive function in outpatients with dementia and mild cognitive impairment compared with community residents without dementia. Journal of Geriatric Cardiology, 2022, 19(8): 594-602. https://doi.org/10.11909/j.issn.1671-5411.2022.08.002
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Abstract Full text About this article
BACKGROUND

It is unclear whether the dementia patients with Alzheimer’s disease (AD) and vascular dementia (VaD) and mixed dementia (MIX, including AD and VaD) would have more developed arterial stiffness as compared with local residents without dementia. The aim of this study was to assess arterial stiffness and cognitive function in different types of dementia patients [AD, VaD, MIX and mild cognitive impairment (MCI)] and community residents without dementia.

METHODS

This was a single-center, cross-sectional observational study. We studied a cohort of 600 elderly outpatients with a complaint of memory loss, who were divided into four groups (AD, VaD, MIX and MCI). In addition, they were compared with 55 age-matched local residents without dementia (Controls). We assessed arterial stiffness by brachial-ankle pulse wave velocity (baPWV) and the global cognitive function by the Mini-Mental State Examination (MMSE).

RESULTS

The baPWV was higher in AD, VaD and MIX than in MCI and in Controls (P < 0.05). The baPWV was higher in MCI than in Controls ( P = 0.021), while MMSE were compatible between them (P = 0.119). The higher baPWV predicted the presence of AD, VaD, MIX and MCI with the odds ratio of 6.46, 8.74, 6.16 and 6.19, respectively. In contrast, there were no difference in baPWV among three different types of dementia (P = 0.191). The linear relationship between baPWV and MMSE was observed in the elderly with MMSE ≥ 23 (R = 0.452, P = 0.033), while it was not in dementia patients (MMSE < 23).

CONCLUSIONS

The findings suggest that MCI and dementia patients have stiffer arteries as compared with age-matched local residents, although global cognitive function may be comparable between MCI and the local residents.


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About this article

Relationship between arterial stiffness and cognitive function in outpatients with dementia and mild cognitive impairment compared with community residents without dementia

Show Author's information Ai Hirasawa1, Kumiko Nagai2, Taiki Miyazawa3, Hitomi Koshiba2, Mami Tamada2, Shigeki Shibata2( ), Koichi Kozaki2
Department of Health and Welfare, Faculty of Health Sciences, Kyorin University, Tokyo, Japan
Department of Geriatric Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan
Department of Health and Sports Science, Faculty of Wellness, Shigakkan University, Aichi, Japan

Abstract

BACKGROUND

It is unclear whether the dementia patients with Alzheimer’s disease (AD) and vascular dementia (VaD) and mixed dementia (MIX, including AD and VaD) would have more developed arterial stiffness as compared with local residents without dementia. The aim of this study was to assess arterial stiffness and cognitive function in different types of dementia patients [AD, VaD, MIX and mild cognitive impairment (MCI)] and community residents without dementia.

METHODS

This was a single-center, cross-sectional observational study. We studied a cohort of 600 elderly outpatients with a complaint of memory loss, who were divided into four groups (AD, VaD, MIX and MCI). In addition, they were compared with 55 age-matched local residents without dementia (Controls). We assessed arterial stiffness by brachial-ankle pulse wave velocity (baPWV) and the global cognitive function by the Mini-Mental State Examination (MMSE).

RESULTS

The baPWV was higher in AD, VaD and MIX than in MCI and in Controls (P < 0.05). The baPWV was higher in MCI than in Controls ( P = 0.021), while MMSE were compatible between them (P = 0.119). The higher baPWV predicted the presence of AD, VaD, MIX and MCI with the odds ratio of 6.46, 8.74, 6.16 and 6.19, respectively. In contrast, there were no difference in baPWV among three different types of dementia (P = 0.191). The linear relationship between baPWV and MMSE was observed in the elderly with MMSE ≥ 23 (R = 0.452, P = 0.033), while it was not in dementia patients (MMSE < 23).

CONCLUSIONS

The findings suggest that MCI and dementia patients have stiffer arteries as compared with age-matched local residents, although global cognitive function may be comparable between MCI and the local residents.

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Publication history
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Acknowledgements

Publication history

Published: 28 August 2022
Issue date: August 2022

Copyright

© 2022 JGC All rights reserved

Acknowledgements

ACKNOWLEDGMENTS

This study was supported by the Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research Grant (15K08931 & 17K18088), and the Health and Labour Sciences Research Grant (H28 Ninchisho-Ippan-003) from the Ministry of Health, Labour and Welfare of Japan. All authors had no conflicts of interest to disclose. The authors appreciate the time and effort spent by all volunteer subjects.

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