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Original Article | Publishing Language: Chinese | Open Access

Study on synthetic process of 18α-glycyrrhizic acid

Yuxing LI, Xueyan MA, Ke ZHAO, Jiaxing ZHAO( )
School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China
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Abstract

In this study, the synthetic process of 18α-glycyrrhizic acid was optimized. Using 18β-glycyrrhizic acid monoammonium salt as the starting material, the target compound 18α-glycyrrhizic acid was obtained through isomerization, esterification, and hydrolysis, with a total yield of 9.43%, purity of 99.23% and key impurity A of 0.17% (HPLC). The optimized process significantly improved the isomerization conversion rate, reduced the formation of related substances, simplified the purification steps, and enhanced both industrial scalability and cost efficiency.

Keywords

18α-glycyrrhizic acidsynthesisprocess optimization
CLC number: R914 Document code: A Article ID: 1000-5048(2026)-3-288-7

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Journal of China Pharmaceutical University
Volume 57 Issue 3,
June 2026
Pages 288-294
DOI: 10.11665/j.issn.1000-5048.2025081501

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Cite this article:
LI Y, MA X, ZHAO K, et al. Study on synthetic process of 18α-glycyrrhizic acid. Journal of China Pharmaceutical University, 2026, 57(3): 288-294. https://doi.org/10.11665/j.issn.1000-5048.2025081501

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Received: 15 August 2025
Published: 25 June 2026
© 2026 The Editorial Office of Journal of China Pharmaceutical University

This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).