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Rapid Communication | Open Access

Xenium spatial transcriptomics identifies mesenchymal fibroblast expansion and conserved fibrotic ECM programs in keloid

Min Deng1, Gregory M. Brewer1, Alejandro Espinoza2,3, Julio Orellana-Montes2,3 , Keshvad Hedayatyanfard1, Chanyue Hu2,3, Md Golam Sarowar Jahan1, Mojan Deriss1, Jeremy C. Davis1, Carol E. Cheng1, Matteo Pellegrini2,3, George W. Agak1( )
Division of Dermatology, Department of Medicine, University of California, UCLA David Geffen School of Medicine, 650 Charles E. Young Dr. S, Los Angeles, CA 90095, United States
Institute for Quantitative and Computational Biosciences, University of California, UCLA David Geffen School of Medicine, 650 Charles E. Young Dr. S, Los Angeles, CA 90095, United States
Department of Molecular Cell and Developmental Biology, University of California, UCLA David Geffen School of Medicine, 650 Charles E. Young Dr. S, Los Angeles, CA 90095, United States
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Burns & Trauma
Volume 14 Issue 4,
April 2026
Article number: tkag056
DOI: 10.1093/burnst/tkag056

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Cite this article:
Deng M, Brewer GM, Espinoza A, et al. Xenium spatial transcriptomics identifies mesenchymal fibroblast expansion and conserved fibrotic ECM programs in keloid. Burns & Trauma, 2026, 14(4): tkag056. https://doi.org/10.1093/burnst/tkag056

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Received: 12 June 2026
Revised: 17 August 2026
Accepted: 17 August 2026
Published: 25 August 2026
© The Author(s) 2026. Published by Oxford University Press.

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