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Rapid Communication | Open Access

Rethinking universal anti-fibrinolysis: a randomized controlled trial on divergent fibrinolytic phenotypes in total knee arthroplasty

Jiacheng Liu1,2,3,‡ , Tao Zhang4,‡, Xuefeng Luo1,2,3,‡, Dehua Wang1,2,3, Runxing Kang1,2,3, Xiangru Shen1,2,3, Yinsong Sun1,2,3, Mingfei Dong1,2,3, Ke Li1,2,3( ), Wei Huang1,2,3 ( ), Yiting Lei1,2,3,5 ( )
Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China
Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China
Orthopaedic Research Laboratory of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China
Department of Orthopedics, Yongchuan Hospital of Chongqing Medical University, No. 439, Xuanhua Road, Yongchuan District, Chongqing 402160, China
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR 999077, China

‡Jiacheng Liu, Tao Zhang and Xuefeng Luo contributed equally.

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Burns & Trauma
Volume 13 Issue 5,
May 2025
Article number: tkaf004
DOI: 10.1093/burnst/tkaf004

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Cite this article:
Liu J, Zhang T, Luo X, et al. Rethinking universal anti-fibrinolysis: a randomized controlled trial on divergent fibrinolytic phenotypes in total knee arthroplasty. Burns & Trauma, 2025, 13(5): tkaf004. https://doi.org/10.1093/burnst/tkaf004

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Received: 13 May 2024
Revised: 14 January 2025
Accepted: 19 January 2025
Published: 10 October 2026
© The Author(s) 2025. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com