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Review

Research progress on the role of fascia in skin wound healing

Jiamin Xu, Hongyan Zhang( ), Haifeng Ye ( )
Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital; School of Basic Medical Sciences; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China
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Highlights

• This review summarizes the role of fascia as a critical structural component of the skin in the process of skin wound healing.

• This review examines the relationship between fascia and chronic wounds, with a particular focus on its role in diabetic foot ulcers and scars.

• This review discusses novel therapeutic strategies targeting the fascia and provides an outlook on future research directions.

Abstract

The skin, the human body’s largest organ, is perpetually exposed to environmental factors, rendering it vulnerable to potential injuries. Fascia, a vital connective tissue that is extensively distributed throughout the body, fulfils multiple functions, including support, compartmentalization, and force transmission. The role of fascia in skin wound healing has recently attracted considerable attention. In addition to providing mechanical support, fascia significantly contributes to intercellular signalling and tissue repair, establishing itself as a crucial participant in wound healing. This review synthesises the latest advancements in fascia research and its implications for skin wound healing.

Keywords

FasciaWound healingSkinSkin regenerationScar tissue

References

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Burns & Trauma
Volume 13 Issue 4,
April 2025
Article number: tkaf002
DOI: 10.1093/burnst/tkaf002

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Cite this article:
Xu J, Zhang H, Ye H. Research progress on the role of fascia in skin wound healing. Burns & Trauma, 2025, 13(4): tkaf002. https://doi.org/10.1093/burnst/tkaf002

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Received: 08 October 2024
Revised: 09 January 2025
Accepted: 17 January 2025
Published: 10 October 2026
Published by Oxford University Press 2025. This work is written by (a) US Government employee(s) and is in the public domain in the US.