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Review | Open Access

The emerging role and therapeutical implications of ferroptosis in wound healing

Yanan Zhao‡, Zhiyang Chen‡, Shenghao Xie, Feng Xiao, Qian Hu ( ), Zhenyu Ju( )
Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental & Regenerative Medicine, College of Life Science and Technology, Jinan University, No. 601, Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China

‡These authors contributed equally.

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Highlights

• Wound healing is a complex biological process that involves multiple steps.

• Ferroptosis is an emerging form of regulated cell death caused by iron-dependent lipid peroxidation. It is regulated by lipid metabolism, iron metabolism, and lipid peroxide repair network.

• Ferroptosis is involved in different stages of normal wound healing and chronic wound healing.

• Ferroptosis holds promise as a potential target for enhancing wound healing.

Abstract

Wound healing is a complex biological process involving multiple steps, including hemostasis, inflammation, proliferation, and remodeling. A novel form of regulated cell death, ferroptosis, has garnered attention because of its involvement in these processes. Ferroptosis is characterized by the accumulation of lipid peroxides and is tightly regulated by lipid metabolism, iron metabolism, and the lipid-peroxide repair network, all of which exert a significant influence on wound healing. This review highlights the current findings and emerging concepts regarding the multifaceted roles of ferroptosis throughout the stages of normal and chronic wound healing. Additionally, the potential of targeted interventions aimed at modulating ferroptosis to improve wound-healing outcomes is discussed.

Keywords

Wound healingFerroptosisIronLipid peroxidationTherapies

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Burns & Trauma
Volume 13 Issue 4,
April 2025
Article number: tkae082
DOI: 10.1093/burnst/tkae082

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Cite this article:
Zhao Y, Chen Z, Xie S, et al. The emerging role and therapeutical implications of ferroptosis in wound healing. Burns & Trauma, 2025, 13(4): tkae082. https://doi.org/10.1093/burnst/tkae082

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Received: 25 July 2024
Revised: 11 November 2024
Accepted: 03 December 2024
Published: 10 October 2026
© The Author(s) 2025. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.