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Review | Open Access

Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity

Kang Huang1,2,‡, Bobin Mi1,2,‡, Yuan Xiong1,2,‡ , Zicai Fu1,2, Wenyun Zhou1,2, Wanjun Liu1,2, Guohui Liu1,2 ( ), Guandong Dai1,2 ( )
Department of Orthopedics, Southern Medical University Pingshan Hospital, No. 19 Renmin Street, Pingshan District, Shenzhen City, Guangdong Province, 518118, P.R. China
Department of Orthopedics, Pingshan District Peoples’Hospital of Shenzhen, No. 19 Renmin Street, Pingshan District, Shenzhen City, Guangdong Province, 518118, P.R. China

‡These authors contributed equally to this work.

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Abstract

Diabetes mellitus, a pervasive chronic metabolic disorder, is often associated with complications such as impaired wound healing. Various factors, most notably vascular deficiency, govern the wound repair process in diabetic patients, significantly impeding diabetic wound healing; therefore, angiogenesis and its role in diabetic wound repair have emerged as important areas of research. This review aims to delve into the mechanisms of angiogenesis, the effects of diabetes on angiogenesis, and the association between angiogenesis and diabetic wound repair. This will ultimately offer valuable guidance regarding the ideal timing of diabetic wound treatment in a clinical setting.

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Burns & Trauma
Article number: tkae052

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Cite this article:
Huang K, Mi B, Xiong Y, et al. Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns & Trauma, 2025, 13(3): tkae052. https://doi.org/10.1093/burnst/tkae052

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Received: 20 January 2024
Revised: 23 July 2024
Accepted: 09 August 2024
Published: 10 October 2026
© The Author(s) 2025. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.