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Review | Open Access

Single-cell sequencing technology in skin wound healing

Xu Cheng Cheng1 , Wang Zi Tong1 , Wang Rui1, Zhao Feng2, Hou Shuai1, Wang Zhe1 ( )
Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, No. 36 Sanhao Street, Shenyang 110004, China
Department of Stem Cells and Regenerative Medicine, China Medical University, No. 77 Puhe Road, Shenyang 110013, China
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Highlights

• Recent advancements in progressive SCS technology have ushered in a paradigm shift in the biomedical field, particularly in the realm of wound healing.

• Gene expression analysis of diverse individual cells within the periwound tissue, especially through SCS, unveils the daedal regulatory patterns at distinct wound healing stages. Incorporating SCS insights into clinical practice is conducive to facilitating personalized treatment, enhancing the accuracy of prognostic risk assessment, and optimizing drug delivery strategies.

• Comparative gene analysis between normal skin and injured tissue, by utilizing SCS, assists in identifying potential biomarkers closely associated with wound repair. This, in turn, helps in the development of novel tactics to accelerate wound healing and minimize scar formation.

Abstract

Skin wound healing is a complicated biological process that mainly occurs in response to injury, burns, or diabetic ulcers. It can also be triggered by other conditions such as dermatitis and melanoma-induced skin cancer. Delayed healing or non-healing after skin injury presents an important clinical issue; therefore, further explorations into the occurrence and development of wound healing at the cellular and molecular levels are necessary. Single-cell sequencing (SCS) is used to sequence and analyze the genetic messages of a single cell. Furthermore, SCS can accurately detect cell expression and gene sequences. The use of SCS technology has resulted in the emergence of new concepts pertaining to wound healing, making it an important tool for studying the relevant mechanisms and developing treatment strategies. This article discusses the application value of SCS technology, the effects of the latest research on skin wound healing, and the value of SCS technology in clinical applications. Using SCS to determine potential biomarkers for wound repair will serve to accelerate wound healing, reduce scar formation, optimize drug delivery, and facilitate personalized treatments.

Keywords

Single-cell sequencingWound healingDNA sequencingRNA sequencingEpigenetic sequencingSkinScarDiabetic ulcer

References

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Burns & Trauma
Volume 12,
December 2024
Article number: tkae043
DOI: 10.1093/burnst/tkae043

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Cite this article:
Cheng XC, Tong WZ, Rui W, et al. Single-cell sequencing technology in skin wound healing. Burns & Trauma, 2024, 12: tkae043. https://doi.org/10.1093/burnst/tkae043

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Received: 09 September 2023
Revised: 24 January 2024
Accepted: 29 January 2024
Published: 10 October 2026
© The Author(s) 2024. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.