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Research Article | Open Access

Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing

Xinyue Zhang1,2,†, Jiahua Huang3,†, Jing Zhao4,†, Lisha Li1,2, Fengze Miao1,2, Tingrui Zhang1,2, Zhongjian Chen1,2, Xing Zhou5( ), Zongguang Tai1,2 ( ), Quangang Zhu1,2 ( )
Shanghai Skin Disease Hospital, School of Medicine, Tongji University, 1278 Baode Road, Shanghai 200443, China
Shanghai Engineering Research Center for Topical Chinese Medicine, 1278 Baode Road, Shanghai 200443, China
Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Shanghai 201500, China
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan 430014, Hubei, China
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, 1168 Chunrong West Road, Kunming 650500, Yunnan, China

†Xinyue Zhang, Jiahua Huang and Jing Zhao contributed equally to this work.

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Highlights

• Fibroblasts and matrine are gradiently extruded to generate MHEM, which exhibit a good encapsulation rate of matrine.

• MHEM exert a therapeutic function throughout all stages of wound healing, thereby effectively facilitating the process of wound healing.

Abstract

Background

Chronic skin wounds are a leading cause of hospital admissions and reduced life expectancy among older people and individuals with diabetes. Delayed wound healing is often attributed to a series of cellular abnormalities. Matrine, a well-studied component found in Sophora flavescens, is recognized for its anti-inflammatory effects. However, its impact on wound healing still remains uncertain. This study aims to explore the potential of matrine in promoting wound healing.

Methods

In this study, we utilized gradient extrusion to produce fibroblast-derived exosome-mimetic vesicles as carriers for matrine (MHEM). MHEM were characterized using transmission electron microscopy and dynamic light scattering analysis. The therapeutic effect of MHEM in wound healing was explored in vitro and in vivo.

Results

Both matrine and MHEM enhanced the cellular activity as well as the migration of fibroblasts and keratinocytes. The potent anti-inflammatory effect of matrine diluted the inflammatory response in the vicinity of wounds. Furthermore, MHEM worked together to promote angiogenesis and the expression of transforming growth factor β and collagen I. MHEM contained growth factors of fibroblasts that regulated the functions of fibroblasts, keratinocytes and monocytes, which synergistically promoted wound healing with the anti-inflammatory effect of matrine.

Conclusions

MHEM showed enhanced therapeutic efficacy in the inflammatory microenvironment, for new tissue formation and angiogenesis of wound healing.

Keywords

Wound healingExosome-mimetic vesiclesMatrineAnti-inflammatory effectAngiogenesis

References

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Burns & Trauma
Volume 12,
December 2024
Article number: tkae015
DOI: 10.1093/burnst/tkae015

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Cite this article:
Zhang X, Huang J, Zhao J, et al. Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing. Burns & Trauma, 2024, 12: tkae015. https://doi.org/10.1093/burnst/tkae015

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Received: 26 October 2023
Revised: 11 December 2023
Accepted: 17 March 2024
Published: 10 October 2026
© The Author(s) 2024. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com