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Review | Open Access

New bioactive secondary metabolites from fungi: 2024

Meiyan Baoa,b,*, Ying Shia,b,*, Xiaoyi Gonga, Yutong Guoa, Jing Wanga, Xiaofei Chena, Ling Liua,b ( )
State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China

*These authors contributed equally to this work.

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Abstract

Fungi have been recognised as a prolific source of structurally unique secondary metabolites with promising pharmacological properties. This review comprehensively summarises the chemical architectures, bioactivities, and research strategies for new fungal-derived natural products, focusing on representative studies published in 2024. A total of 907 novel fungal-derived compounds are systematically cataloged (isomers are also contained in the total count), including 284 polyketides, 362 terpenoids, 28 steroids, 108 alkaloids, 75 peptides, and 50 glycosides, while highlighting cutting-edge methodologies such as metabolomics-guided discovery platforms and biosynthetic pathway engineering. By establishing connections between chemical novelty and therapeutic value, this review not only provides strategic guidance for fungal chemical diversity exploration but also illuminates their transformative potential in overcoming drug discovery bottlenecks.

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Keywords

Fungal natural productsnovel structureschemical investigationbioactivitiesresearch strategies

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Mycology
Volume 16 Issue 3,
September 2025
Pages 961-987
DOI: 10.1080/21501203.2025.2526772

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Cite this article:
Bao M, Shi Y, Gong X, et al. New bioactive secondary metabolites from fungi: 2024. Mycology, 2025, 16(3): 961-987. https://doi.org/10.1080/21501203.2025.2526772

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Received: 15 May 2025
Accepted: 24 June 2025
Published: 11 July 2025
© 2025 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.