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Review | Open Access

Progress in the application of nanoparticles for the treatment of fungal infections: A review

Xinlin Zhua,#, Youming Chenb,#, Dan Yuc,#, Wenjie Fanga, Wanqing Liaoa( ), Weihua Pana( )
Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai, China
Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
Department of General Practice, Second Affiliated Hospital of Naval Medical University, Shanghai, China

# Xinlin Zhu, Youming Chen and Dan Yu equally contributed to this study.

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Abstract

The burden of fungal infections on human health is increasing worldwide. Aspergillus, Candida, and Cryptococcus are the top three human pathogenic fungi that are responsible for over 90% of infection-related deaths. Moreover, effective antifungal therapeutics are lacking, primarily due to host toxicity, pathogen resistance, and immunodeficiency. In recent years, nanomaterials have proved not only to be more efficient antifungal therapeutic agents but also to overcome resistance against fungal medication. This review will examine the limitations of standard antifungal therapy as well as focus on the development of nanomaterials.

Keywords

Fungal infectionantifungalnanoparticle

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Mycology
Volume 15 Issue 1,
March 2024
Pages 1-16
DOI: 10.1080/21501203.2023.2285764

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Cite this article:
Zhu X, Chen Y, Yu D, et al. Progress in the application of nanoparticles for the treatment of fungal infections: A review. Mycology, 2024, 15(1): 1-16. https://doi.org/10.1080/21501203.2023.2285764

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Received: 21 May 2023
Accepted: 28 October 2023
Published: 08 December 2023
© 2023 The Author(s).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.