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Review | Open Access

Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

Guizheng Wei1,2,3 , Ke Lu2,3 , Muhammad Umar2,3, Zhenglin Zhu4, William W. Lu3, John R. Speakman5, Yan Chen1( ), Liping Tong2( ), Di Chen2,3
Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Department of Orthopedic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

These authors contributed equally: Guizheng Wei and Ke Lu.

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Abstract

Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type Ⅱ diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.

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Bone Research
Volume 11,
2023
Article number: 63
DOI: 10.1038/s41413-023-00301-9

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Cite this article:
Wei G, Lu K, Umar M, et al. Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms. Bone Research, 2023, 11: 63. https://doi.org/10.1038/s41413-023-00301-9

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Received: 06 September 2023
Revised: 11 October 2023
Accepted: 27 October 2023
Published: 06 December 2023
© The Author(s) 2023

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