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Original Article | Open Access

Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway

Yu Liu1, Xiangxian Zhang1, Wei Wang1, Ting Liu2, Jun Ren3, Siyuan Chen1, Tianqi Lu1, Yan Tie1, Xia Yuan1, Fei Mo1, Jingyun Yang1, Yuquan Wei1, Xiawei Wei1 ( )
Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan 610041, PR China
Department of Clinical Laboratory, The West China Second University Hospital of Sichuan University (WCSUH-SCU), Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan 610041, PR China
Department of Prenatal Diagnosis Center, The West China Second University Hospital of Sichuan University (WCSUH-SCU), Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan 610041, PR China
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Abstract

Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-derived mesenchymal stem cells, multipotent stem cells with high expression of glutamine synthetase (GS) in bone marrow, ammonia and glutamate can be converted to glutamine via glutamine synthetase activity to support the proliferation of MSCs. As a major nutritional amino acid for biosynthesis, glutamine can activate the Akt/mTOR/S6k pathway to stimulate cell proliferation. The activation of mTOR can promote cell entry into S phase, thereby enhancing DNA synthesis and cell proliferation. Our studies demonstrated that mesenchymal stem cells can convert the toxic waste product ammonia into nutritional glutamine via GS activity. Then, the Akt/mTOR/S6k pathway is activated to promote bone marrow-derived mesenchymal stem cell proliferation. These results suggest a new therapeutic strategy and potential target for the treatment of diseases involving hyperammonemia.

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Bone Research
Volume 10,
2022
Article number: 57
DOI: 10.1038/s41413-022-00215-y

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Liu Y, Zhang X, Wang W, et al. Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway. Bone Research, 2022, 10: 57. https://doi.org/10.1038/s41413-022-00215-y

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Received: 13 November 2021
Revised: 28 February 2022
Accepted: 20 March 2022
Published: 26 August 2022
© The Author(s) 2022

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