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Review | Open Access

Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair

Sipin Zhu1,2,3, Min Chen1, Yibo Ying1, Qiuji Wu1, Zhiyang Huang1, Wenfei Ni1, Xiangyang Wang1, Huazi Xu1, Samuel Bennett3, Jian Xiao1,2 ( ), Jiake Xu1,3 ( )
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
Molecular Pharmacology Research Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
Molecular Laboratory, School of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia
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Abstract

Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury (SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics.

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Bone Research
Volume 10,
2022
Article number: 30
DOI: 10.1038/s41413-022-00203-2

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Cite this article:
Zhu S, Chen M, Ying Y, et al. Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair. Bone Research, 2022, 10: 30. https://doi.org/10.1038/s41413-022-00203-2

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Received: 17 November 2020
Revised: 16 December 2021
Accepted: 17 January 2022
Published: 16 March 2022
© The Author(s) 2022

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