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Original Article | Open Access

Stem cell microencapsulation maintains stemness in inflammatory microenvironment

Yajun Zhao1,2 , Yilin Shi1, Huiqi Yang1, Mengmeng Liu1, Lanbo Shen1, Shengben Zhang1, Yue Liu1, Jie Zhu3, Jing Lan1, Jianhua Li1 ( ), Shaohua Ge1( )
Department of Implantology & Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, China
Airong Plastic Surgery Hospital, Jinan, China
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Abstract

Maintaining the stemness of the transplanted stem cell spheroids in an inflammatory microenvironment is challenging but important in regenerative medicine. Direct delivery of stem cells to repair periodontal defects may yield suboptimal effects due to the complexity of the periodontal inflammatory environment. Herein, stem cell spheroid is encapsulated by interfacial assembly of metal-phenolic network (MPN) nanofilm to form a stem cell microsphere capsule. Specifically, periodontal ligament stem cells (PDLSCs) spheroid was coated with FeⅢ/tannic acid coordination network to obtain spheroid@[FeⅢ-TA] microcapsules. The formed biodegradable MPN biointerface acted as a cytoprotective barrier and exhibited antioxidative, antibacterial and anti-inflammatory activities, effectively remodeling the inflammatory microenvironment and maintaining the stemness of PDLSCs. The stem cell microencapsulation proposed in this study can be applied to multiple stem cells with various functional metal ion/polyphenol coordination, providing a simple yet efficient delivery strategy for stem cell stemness maintenance in an inflammatory environment toward a better therapeutic outcome.

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International Journal of Oral Science
Volume 14,
2022
Article number: 48
DOI: 10.1038/s41368-022-00198-w

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Cite this article:
Zhao Y, Shi Y, Yang H, et al. Stem cell microencapsulation maintains stemness in inflammatory microenvironment. International Journal of Oral Science, 2022, 14: 48. https://doi.org/10.1038/s41368-022-00198-w

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Accepted: 22 August 2022
Published: 10 October 2022
© The Author(s) 2022

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