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Review | Open Access

Immunomodulatory effects and mechanisms of distraction osteogenesis

Shude Yang1,2, Ning Wang1, Yutong Ma3, Shuaichen Guo4, Shu Guo1( ), Hongchen Sun2( )
Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, China
Liaoning Provincial Key Laboratory of Oral Diseases, School of Stomatology and Department of Oral Pathology, School of Stomatology, China Medical University, Shenyang, China
Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, China
China Medical University, Shenyang, China
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Abstract

Distraction osteogenesis (DO) is widely used for bone tissue engineering technology. Immune regulations play important roles in the process of DO like other bone regeneration mechanisms. Compared with others, the immune regulation processes of DO have their distinct features. In this review, we summarized the immune-related events including changes in and effects of immune cells, immune-related cytokines, and signaling pathways at different periods in the process of DO. We aim to elucidated our understanding and unknowns about the immunomodulatory role of DO. The goal of this is to use the known knowledge to further modify existing methods of DO, and to develop novel DO strategies in our unknown areas through more detailed studies of the work we have done.

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International Journal of Oral Science
Volume 14,
2022
Article number: 4
DOI: 10.1038/s41368-021-00156-y

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Cite this article:
Yang S, Wang N, Ma Y, et al. Immunomodulatory effects and mechanisms of distraction osteogenesis. International Journal of Oral Science, 2022, 14: 4. https://doi.org/10.1038/s41368-021-00156-y

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Received: 13 September 2021
Revised: 20 December 2021
Accepted: 29 December 2021
Published: 24 January 2022
© The Author(s) 2022

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