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Original Article | Open Access

A new PAT application: Optimization of processing methods for honeysuckle flower (Lonicerae Japonicae Flos) and wild honeysuckle flower (Lonicerae Flos)

Jiangbo Haoa,b,1, Zhisheng Wua,c,d,1, Weidong Lia,b ( ), Zhongshuang Zhanga,b, Jinrui Gua,b
School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China
Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs, Ministry of Education, Beijing 100102, China
Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM), Ministry of Education, Beijing 100102, China
Key Laboratory of TCM-information Engineering, State Administration of TCM, Beijing 100102, China

Peer review under responsibility of Beijing University of Chinese Medicine.

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Abstract

Objective

A novel processing analytical framework of Chinese Material Medica (CMM) includes breeding process analysis, planting process analysis, producing process analysis and manufacture process analysis. In order to study this framework, we used quality control of honeysuckle flower (Lonicerae japonicae Flos) including diploid and tetraploid Lonicera japonica, and wild honeysuckle flower (Lonicerae Flos) including Lonicerae hypoglauca, Lonicerae confusa, Lonicerae fulvotomentosa and Lonicerae macranthoides as an example.

Methods

A total of 360 samples were analyzed from three variables including species, growing areas, and optimization of processing methods. For quantitative analysis, chlorogenic acid (CA), isochlorogenic acid A (3, 5-DCA), and isochlorogenic acid C (4, 5-DCA) were measured with high performance liquid chromatography (HPLC).

Results

The three organic acids contents are higher in wild honeysuckle flower than honeysuckle flower; L. japonica (tetraploid) is higher than L. japonica (diploid). Modern processing methods (kill-enzyme torrefaction and fixing machine drying) are popular in growing areas and are superior to traditional methods (sun and shade drying).

Conclusions

Novel process analysis concepts in processing analytical technology (PAT) enriched the Chinese Material Medica contents.

Keywords

Honeysuckle flowerWild honeysuckle flowerProcessing analytical technologyQuality controlProcessing method

References

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Journal of Traditional Chinese Medical Sciences
Volume 5 Issue 2,
April 2018
Pages 199-205
DOI: 10.1016/j.jtcms.2018.03.007

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Cite this article:
Hao J, Wu Z, Li W, et al. A new PAT application: Optimization of processing methods for honeysuckle flower (Lonicerae Japonicae Flos) and wild honeysuckle flower (Lonicerae Flos). Journal of Traditional Chinese Medical Sciences, 2018, 5(2): 199-205. https://doi.org/10.1016/j.jtcms.2018.03.007

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Received: 25 March 2017
Revised: 28 February 2018
Accepted: 20 March 2018
Published: 27 March 2018
© 2018 Beijing University of Chinese Medicine.

This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).