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Journal of Neurorestoratology 2023, 11(3): 100071 https://doi.org/10.1016/j.jnrt.2023.100071
Review | Open Access | Issue | Published: 28 July 2023

Recent advancements in interventions for cerebral palsy – A review

Show Author's Information Priya Sharma,  Meena Gupta( ),  Ruchika Kalra
Amity Institute of Health Allied Science, Department of Physiotherapy, Amity University, Sector-125, Noida, Uttar Pradesh, India
Keywords:
Cerebral palsy, Music therapy, Neuroplasticity, Neurofeedback, Repetitive transcranial magnetic stimulation, Computer–brain interface
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Sharma P, Gupta M, Kalra R. Recent advancements in interventions for cerebral palsy – A review. Journal of Neurorestoratology, 2023, 11(3): 100071. https://doi.org/10.1016/j.jnrt.2023.100071
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Abstract Full text About this article

Non-progressive conditions that develop in the growing fetus or newborn brain and result in lifelong motor impairments and activity restrictions are collectively referred to as cerebral palsy. In the present review, recent advancements in the treatment of cerebral palsy are discussed. Studies are currently being conducted on high-tech aids such as telemedicine, robotics, virtual reality, telerehabilitation, and exoskeletons. In the current review, we focus on the effectiveness of interventions including neurologic music therapy, aquatic therapy, virtual reality, robotics, electrical stimulation, constraint-induced movement therapy, hippotherapy, and hyperbaric oxygen therapy. We also discuss the drugs used for the treatment of spasticity in cerebral palsy, as well as the effects of nutritional intake. Neurologic music therapy alongside physiotherapy leads to positive rehabilitation outcomes, as does treadmill gait training combined with robotics for lower limb improvements. Furthermore, kinesio taping is helpful for positioning the wrist, thumb, and fingers, and for reducing upper limb stiffness. Neurorestorative therapies such as cell therapy, brain–computer interface technology, and transcranial magnetic stimulation may also effectively restore neural networks in a positive direction in cerebral palsy. Finally, rehabilitation along with neurofeedback and biofeedback is considered helpful in patients with this neurological disorder.


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About this article

Recent advancements in interventions for cerebral palsy – A review

Show Author's information Priya Sharma, Meena Gupta( ), Ruchika Kalra
Amity Institute of Health Allied Science, Department of Physiotherapy, Amity University, Sector-125, Noida, Uttar Pradesh, India

Abstract

Non-progressive conditions that develop in the growing fetus or newborn brain and result in lifelong motor impairments and activity restrictions are collectively referred to as cerebral palsy. In the present review, recent advancements in the treatment of cerebral palsy are discussed. Studies are currently being conducted on high-tech aids such as telemedicine, robotics, virtual reality, telerehabilitation, and exoskeletons. In the current review, we focus on the effectiveness of interventions including neurologic music therapy, aquatic therapy, virtual reality, robotics, electrical stimulation, constraint-induced movement therapy, hippotherapy, and hyperbaric oxygen therapy. We also discuss the drugs used for the treatment of spasticity in cerebral palsy, as well as the effects of nutritional intake. Neurologic music therapy alongside physiotherapy leads to positive rehabilitation outcomes, as does treadmill gait training combined with robotics for lower limb improvements. Furthermore, kinesio taping is helpful for positioning the wrist, thumb, and fingers, and for reducing upper limb stiffness. Neurorestorative therapies such as cell therapy, brain–computer interface technology, and transcranial magnetic stimulation may also effectively restore neural networks in a positive direction in cerebral palsy. Finally, rehabilitation along with neurofeedback and biofeedback is considered helpful in patients with this neurological disorder.

Keywords: Cerebral palsy, Music therapy, Neuroplasticity, Neurofeedback, Repetitive transcranial magnetic stimulation, Computer–brain interface

References(118)

1

Sadowska M, Sarecka-Hujar B, Kopyta I. Cerebral palsy: current opinions on definition, epidemiology, risk factors, classification and treatment options. Neuropsychiatr Dis Treat. 2020;16: 1505-1518.
DOI Google Scholar
2

Alok S, Geng TC, Sane H, et al. Clinical neurorestorative progresses in cerebral palsy. J Neurorestoratol. 2017;5: 51-57.
DOI Google Scholar
3

Schroeder AS, Homburg M, Warken B, et al. Prospective controlled cohort study to evaluate changes of function, activity and participation in patients with bilateral spastic cerebral palsy after Robot-enhanced repetitive treadmill therapy. Eur J Paediatr Neurol. 2014;18(4):502-510.
DOI Google Scholar
4

Novak I, Morgan C, Fahey M, et al. State of the evidence traffic lights 2019: systematic review of interventions for preventing and treating children with cerebral palsy. Curr Neurol Neurosci Rep. 2020;20(2):3.
DOI Google Scholar
5
Sarah Mcintyre, Nadia Badawi, Isabelle Balde, et al. Australian Cerebral Palsy Register Report Authors Australian Capital Territory and New South Wales. 2018.
6

Morgan P, McGinley J. Gait function and decline in adults with cerebral palsy: a systematic review. DisabilRehabil. 2014;36(1):1-9.
DOI Google Scholar
7

Gao J, He LN, Yu XF, et al. Rehabilitation with a combination of scalp acupuncture and exercise therapy in spastic cerebral palsy. Complement Ther Clin Pract 2019;35: 296-300.
DOI Google Scholar
8

Sharma HS, Chopp M, Chen L, et al. The 2021 yearbook of neurorestoratology. J Neurorestoratol. 2022;10(3):100008.
DOI Google Scholar
9

Ritzmann R, Stark C, Krause A. Vibration therapy in patients with cerebral palsy: a systematic review. Neuropsychiatr Dis Treat. 2018;14: 1607-1625.
DOI Google Scholar
10

Marrades-Caballero E, Santonja-Medina CS, Sanz-Mengibar JM, et al. Neurologic music therapy in upper-limb rehabilitation in children with severe bilateral cerebral palsy: a randomized controlled trial. Eur J Phys Rehabil Med. 2018;54(6):866-872.
DOI Google Scholar
11

Amirthalingam J, Paidi G, Alshowaikh K, et al. Virtual reality intervention to help improve motor function in patients undergoing rehabilitation for cerebral palsy, Parkinson's disease, or stroke: asystematic review of randomized controlled trials. Cureus 2021,13(7):e16763.
DOI Google Scholar
12

Huang H, Sharma HS, Chen L, et al. Neurorestoratology: New advances in clinical therapy. CNS Neurol Disord Drug Targets. 2023;22(7):1031-1038.
DOI Google Scholar
13

Jang-won L, Kyun KY, Hwa CJ, et al. The Effectiveness of Music Therapy on Cerebral Palsy Patients Receiving Rehabilitation Treatment. International Journal of Humanities and Social Science Invention. 2016;5(9):24-29.
Google Scholar
14

Baram, Y,Lenger, R. Gait improvement in patients with cerebral palsy by visual and auditory feedback. Neuromodulation. 2012;15(1):48-52.
DOI Google Scholar
15

Cano-de-la-Cuerda R, Molero-Sanchez A, Carratala-Tejada M, et al. Theories and control models and motor learning: clinical applications in neuro-rehabilitation. Neurologia. 2015;30(1):32-41.
DOI Google Scholar
16

Vinolo-Gil MJ, Casado-Fernández E, Perez-Cabezas V, et al. Effects of the combination of music therapy and physiotherapy in the improvement of motor function in cerebral palsy: achallenge for research. Children. 2021;8(10):868.
DOI Google Scholar
17

Chong HJ, Cho SR, Jeong E, Kim SJ. Finger exercise with keyboard playing in adults with cerebral palsy: A preliminary study. J Exerc Rehabil. 2013;9(4):420-425.
DOI Google Scholar
18

Simon-Martinez C, Mailleux L, Jaspers E, et al. Effects of combining constraint-induced movement therapy and action-observation training on upper limb kinematics in children with unilateral cerebral palsy: a randomized controlled trial. SciRep. 2020;10(1):10421.
DOI Google Scholar
19

Chen HC, Chen CL, Kang LJ, et al. Improvement of upper extremity motor control and function after home-based constraint induced therapy in children with unilateral cerebral palsy: immediate and long-term effects. Arch Phys Med Rehabil. 2014;95(8):1423-1432.
DOI Google Scholar
20

Eliasson AC, Nordstrand L, Ek L, et al. The effectiveness of Baby-CIMT in infants younger than 12 months with clinical signs of unilateral-cerebral palsy; an explorative study with randomized design. Res Dev Disabil. 2018;72: 191-201.
DOI Google Scholar
21

Ramey SL, DeLuca S, Stevenson RD, et al. Children with Hemiparesis Arm and Movement Project (CHAMP): protocol for a multisite comparative efficacy trial of paediatric constraint-induced movement therapy (CIMT) testing effects of dosage and type of constraint for children with hemiparetic cerebral palsy. BMJ Open. 2019;9(1):e023285.
DOI Google Scholar
22

Weiss PL, Tirosh E, Fehlings D. Role of virtual reality for cerebral palsy management. J Child Neurol. 2014;29(8):1119-1124.
DOI Google Scholar
23

Cho C, Hwang W, Hwang S, et al. Treadmill training with virtual reality improves gait, balance, and muscle strength in children with cerebral palsy. Tohoku J Exp Med. 2016;238(3):213-218.
DOI Google Scholar
24

Metin Ökmen B, Doğan Aslan M, Nakipoğlu Yüzer GF, et al. Effect of virtual reality therapy on functional development in children with cerebral palsy: a single-blind, prospective, randomized-controlled study. Turk J Phys Med Rehabil. 2019;65(4):371-378.
DOI Google Scholar
25

Weiss PL, Tirosh E, Fehlings D. Role of virtual reality for cerebral palsy management. JChild Neurol. 2014;29(8):1119-1124.
DOI Google Scholar
26

El-Shamy, SM, El Kafy, EMA. Effect of functional electrical stimulation on postural control in children with hemiplegic cerebral palsy: a randomized controlled trial. Bull Fac Phys Ther. 2021;26:22.
DOI Google Scholar
27

Moll I, Vles JSH, Soudant DLHM, et al. Functional electrical stimulation of the ankle dorsiflexors during walking in spastic cerebral palsy: a systematic review. DevMed Child Neurol. 2017;59(12):1230-1236.
DOI Google Scholar
28

Christine Singleton, Helen Jones, Lizz Maycock. Functional electrical stimulation (FES) for children and young people with cerebral palsy. Paediatrics and Child Health. 2019;29(11):498-502.
DOI Google Scholar
29

Bar-On L, Molenaers G, Aertbeliën E, et al. Spasticity and its contribution to hypertonia in cerebral palsy. Biomed ResInt. 2015;2015: 317047.
DOI Google Scholar
30

Karabay İ, Dogan A, Ekiz T, et al. Training postural control and sitting in children with cerebral palsy: Kinesio taping vs. neuromuscular electrical stimulation. Complement Ther Clin Pract. 2016;24:67-72.
DOI Google Scholar
31

Moghaddam SR, Lajvardi L, Amiri A, et al. Investigating the effects of wrist Kinesio Taping on hand function of children with spastic diplegic cerebral palsy. Modern Rehabilitation. 2012;93(3):491-504.
Google Scholar
32

da Costa CS, Rodrigues FS, Leal FM, et al. Pilot study: investigating the effects of Kinesio Taping® on functional activities in children with cerebral palsy. DevNeurorehabil. 2013;16(2):121-128.
DOI Google Scholar
33

Dos Santos AN, Visicatto LP, de Oliveira AB, Rocha NACF. Effects of Kinesio taping in rectus femoris activity and sit-to-stand movement in children with unilateral cerebral palsy: placebo-controlled, repeated-measure design. Disabil Rehabil. 2019;41(17):2049-2059.
DOI Google Scholar
34

Tabatabaee M, Cheraghifard M, Shamsoddini A. The effects of kinesio taping of lower limbs on functional mobility, spasticity, and range of motion of children with spastic cerebral palsy. Egypt J Neurol Psychiatry Neurosurg. 2019;55(1), 1-6.
DOI Google Scholar
35

Güeita-Rodríguez J, García-Muro F, Rodríguez-Fernández ÁL, et al. Preliminary aquatic physical therapy core sets for children and youth with neurological disorders: a consensus process. Pediatr Phys Ther. 2019;31(3):272-278.
DOI Google Scholar
36

Muñoz-Blanco E, Merino-Andrés J, Aguilar-Soto B, et al. Influence of Aquatic Therapy in Children and Youth with Cerebral Palsy: A Qualitative Case Study in a Special Education School. Int J Environ Res Public Health. 2020;17(10):3690.
DOI Google Scholar
38

Akinola BI, Gbiri CA, Odebiyi DO. Effect of a 10-Week Aquatic Exercise Training Program on Gross Motor Function in Children With Spastic Cerebral Palsy. Glob Pediatr Health. 2019;6:2333794X19857378.
DOI Google Scholar
37

Ballington SJ, Naidoo R. The carry-over effect of an aquatic-based intervention in children with cerebral palsy. Afr J Disabil. 2018;7(0):361.
DOI Google Scholar
39

Adar S, Dündar Ü, Demirdal ÜS, et al. The effect of aquatic exercise on spasticity, quality of life, and motor function in cerebral palsy. TurkJPhysMedRehabil. 2017;63(3):239-248.
DOI Google Scholar
40

Kim SJ, Kwak EE, Park ES, et al. Differential effects of rhythmic auditory stimulation and neurodevelopmental treatment/Bobath on gait patterns in adults with cerebral palsy: a randomized controlled trial. Clin Rehabil. 2012;26(10):904-914.
DOI Google Scholar
41

Carvalho I, Pinto SM, Chagas DDV, et al. Robotic gait training for individuals with cerebral palsy: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2017;98(11):2332-2344.
DOI Google Scholar
42

Kawasaki S, Ohata K, Yoshida T, et al. Gait improvements by assisting hip movements with the robot in children with cerebral palsy: a pilot randomized controlled trial. J Neuroeng Rehabil. 2020;17(1):87.
DOI Google Scholar
43

Bortole M, Venkatakrishnan A, Zhu FS, et al. The H2 robotic exoskeleton for gait rehabilitation after stroke: early findings from a clinical study. JNeuroengRehabil. 2015; 12: 54.
DOI Google Scholar
44

Kim SK, Park D, Yoo B, et al. Overground Robot-Assisted Gait Training for Pediatric Cerebral Palsy. Sensors. 2021;21(6):2087.
DOI Google Scholar
45

Wallard L, Dietrich G, Kerlirzin Y, et al. Effect of robotic-assisted gait rehabilitation on dynamic equilibrium control in the gait of children with cerebral palsy. Gait Posture. 2018; 60: 55-60.
DOI Google Scholar
46

Winchester P, McColl R, Querry R, et al. Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury. Neurorehabil Neural Repair. 2005;19(4):313-324.
DOI Google Scholar
47

Beretta E, Storm FA, Strazzer S, et al. Effect of robot-assisted gait training in a large population of children with motor impairment due to cerebral palsy or acquired brain injury. Arch Phys Med Rehabil. 2020;101(1):106-112.
DOI Google Scholar
48

Cherni Y, Ballaz L, Lemaire J, et al. Effect of low dose robotic-gait training on walking capacity in children and adolescents with cerebral palsy. Neurophysiol Clin. 2020;50(6):507-519.
DOI Google Scholar
49

Goswami JN, Sankhyan N, Singhi P. Add-on home-centered activity-based therapy vs conventional physiotherapy in improving walking ability at 6-months in children with diplegic cerebral palsy: arandomized controlled trial. Indian Pediatr. 2021;58(9):826-832.
DOI Google Scholar
50

Johnson RW, Williams SA, Gucciardi DF, et al. Can an online exercise prescription tool improve adherence to home exercise programmes in children with cerebral palsy and other neurodevelopmental disabilities? A randomised controlled trial. BMJ Open. 2020;10(12):e040108.
DOI Google Scholar
51

Whalen CN, Case-Smith J. Therapeutic effects of horseback riding therapy on gross motor function in children with cerebral palsy: a systematic review. PhysOccupTherPediatr. 2012;32(3):229-242.
DOI Google Scholar
52

Park ES, Rha DW, Shin JS, et al. Effects of hippotherapy on gross motor function and functional performance of children with cerebral palsy. Yonsei Med J. 2014;55(6):1736-1742.
DOI Google Scholar
53

Moraes AG, Copetti F, Angelo VR, et al. The effects of hippotherapy on postural balance and functional ability in children with cerebral palsy. J Phys Ther Sci. 2016;28(8):2220-2226.
DOI Google Scholar
54

Jang CH, Joo MC, Noh SE, et al. Effects of hippotherapy on psychosocial aspects in children with cerebral palsy and their caregivers: a pilot study. Annals of rehabilitation medicine. 2016;40(2):230-236.
DOI Google Scholar
55

Matusiak-Wieczorek E, Dziankowska-Zaborszczyk E, Synder M, et al. The influence of hippotherapy on the body posture in a sitting position among children with cerebral palsy. IntJEnvironResPublic Health. 2020;17(18):6846.
DOI Google Scholar
56

Howell RS, Criscitelli T, Woods JS, et al. Hyperbaric oxygen therapy: indications, contraindications, and use at a tertiary care center. AORN J. 2018;107(4):442-453.
DOI Google Scholar
57

Khalil ME, Abdel Ghafar MA, Abdelraouf OR, et al. Long-term effect of hyperbaric oxygen therapy on gait and functional balance skills in cerebral palsy children-arandomized clinical trial. Children. 2023;10(2):394.
DOI Google Scholar
58

Azhar MJ, Zareen A, Saleem Z, et al. Evaluation of role of hyperbaric oxygen therapy in children with cerebral palsy-our experience at armed forces hospital, king abdul aziz naval base. KSA. Pakistan Journal of Medical & Health Sciences. 2017;11(4):1407-1411.
Google Scholar
59

Mukherjee A, Raison M, Sahni T, et al. Intensive rehabilitation combined with HBO2 therapy in children with cerebral palsy: a controlled longitudinal study. Undersea Hyperb Med. 2014;41(2):77-85.
Google Scholar
60

Jain KK, Harch PG. HBO in the management of cerebral palsy. Textbook of Hyperbaric Medicine. 2017:351-364.
DOI Google Scholar
61

Gupta M, Bhatia D, Rajak BL. Study of available intervention techniques to improve cognitive function in cerebral palsy patients. Current Neurobiology. 2017;8(2):51-59.
Google Scholar
62

Gupta M, Rajak BL, Bhatia D, et al. Transcranial magnetic stimulation therapy in spastic cerebral palsy children improves motor activity. J Neuroinfect Dis 2016;7(4).
DOI Google Scholar
63

Meena Gupta, Dinesh Bhatia, Tapas Kumar Sinha, et al. Investigation of cognitive changes in cerebral palsy children employing different integrated sensing techniques. Sens Int. 2020;1:100016.
DOI Google Scholar
64

Guo ZW, Xing GQ, He B, et al. Dynamic modulation of rTMS on functional connectivity and functional network connectivity to children with cerebral palsy: a case report. Neuroreport. 2016;27(4):284-288.
DOI Google Scholar
65

Rajak BL, Gupta M, Bhatia D, et al. Increasing number of therapy Sessions of repetitive transcranial magnetic stimulation improves motor development by reducing muscle spasticity in cerebral palsy children. Ann Indian Acad Neurol. 2019;22(3):302-307.
DOI Google Scholar
66

D'Agati D, Bloch Y, Levkovitz Y, et al. rTMS for adolescents: safety and efficacy considerations. Psychiatry Res. 2010;177(3):280-285.
DOI Google Scholar
67
Gupta M, Bhatia D. Study the cognitive changes in cerebral palsy children employing repetitive transcranial magnetic stimulation and neurofeedback training. In: Proceedings of the International Conference on Computing and Communication Systems. Singapore: Springer Singapore; 2021:431-439.
DOI
68
Ponce P, Molina A, DavidC, et al. Brain computer interfaces for cerebral palsy. In: InCerebral Palsy - Challenges for the Future. InTech; 2014.
DOI
69

Kim TW, Lee BH. Clinical usefulness of brain-computer interface-controlled functional electrical stimulation for improving brain activity in children with spastic cerebral palsy: a pilot randomized controlled trial. J Phys Ther Sci. 2016;28(9):2491-2494.
DOI Google Scholar
70

Ramírez ARG, Da Silva JF, Savall ACR, et al. User's emotions and usability study of a brain-computer interface applied to people with cerebral palsy. Technologies. 2018;6(1):28.
DOI Google Scholar
71

Zhang J, Jadavji Z, Zewdie E, et al. Evaluating if children can use simple brain computer interfaces. Front Hum Neurosci. 2019;13:24.
DOI Google Scholar
72

Huang H, Bach JR, Sharma HS, et al. The 2022 yearbook of Neurorestoratology. J Neurorestoratol. 2023:100054.
DOI Google Scholar
73

Bobrov PD, Biryukova EV, Polyaev BA, et al. Rehabilitation of patients with cerebral palsy using hand exoskeleton controlled by brain-computer interface. Bull Russ State Med Univ. 2020(4):33-40.
DOI Google Scholar
74

Lu Z, Ilieva R, Ivanova M. Interactive interface module for cerebral palsy rehabilitation: study on the performance through machine learning. Complex Control Systems. 2022;4(1):36-40.
Google Scholar
75

Jadavji Z, Zewdie E, Kelly D, et al. Establishing a clinical brain-computer interface program for children with severe neurological disabilities. Cureus. 2022;14(6):e26215.
DOI Google Scholar
76

Huggins JE, Karlsson P, Warschausky SA. Challenges of brain-computer interface facilitated cognitive assessment for children with cerebral palsy. Front Hum Neurosci. 2022;16: 977042.
DOI Google Scholar
77

Huang HY, Young W, Ziad A, et al. Beijing declaration of international association of neurorestoratology. J Neurorestoratol. 2015:121.
DOI Google Scholar
78

Huang HY, Young W, Chen L, et al. Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2017). Cell Transplant. 2018;27(2):310-324.
DOI Google Scholar
79

Lv ZY, Li Y, Liu J. Progress in clinical trials of stem cell therapy for cerebral palsy. Neural Regen Res. 2021;16(7):1377-1382.
DOI Google Scholar
80

Kim H, Na DL, Lee NK, et al. Intrathecal injection in A rat model: a potential route to deliver human Whartons' jelly-derived mesenchymal stem cells into the brain. Int J Mol Sci. 2020;21(4):1272.
DOI Google Scholar
81

Jin J. Stem cell treatments. JAMA. 2017;317(3):330.
DOI Google Scholar
82

Shroff G, Das L. Human Embryonic Stem Cell Therapy in Cerebral Palsy Children with Cortical Visual Impairment: A Case Series of 40 Patients. J Cell Sci Ther. 2014;5(6):189.
Google Scholar
83

Smith MJ, Finch-Edmondson M, Miller SL, et al. Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community. Stem Cell Res Ther. 2023;14(1):18.
DOI Google Scholar
84

Sun JM, Kurtzberg J. Stem cell therapies in cerebral palsy and autism spectrum disorder. Dev Med Child Neurol. 2021;63(5):503-510.
DOI Google Scholar
85

Min K, Suh MR, Cho KH, et al. Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2×2 factorial randomized placebo-controlled trial. Stem Cell Res Ther. 2020;11(1):509.
DOI Google Scholar
86

Kang M, Min K, Jang J, et al. Involvement of immune responses in the efficacy of cord blood cell therapy for cerebral palsy. Stem Cells Dev. 2015;24(19):2259-2268.
DOI Google Scholar
87

Sun JM, Case LE, McLaughlin C, et al. Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: an open-label, randomized trial. Dev Med Child Neurol. 2022;64(12):1477-1486.
DOI Google Scholar
88

Kikuchi H, Saitoh S, Tsuno T, et al. Safety and feasibility of autologous cord blood infusion for improving motor function in young children with cerebral palsy in Japan: a single-center study. Brain Dev. 2022;44(10):681-689.
DOI Google Scholar
89

Hilgenberg AM, Cardoso CC, Caldas FF, et al. Hearing rehabilitation in cerebral palsy: development of language and hearing after cochlear implantation. Braz J Otorhinolaryngol. 2015;81(3):240-247.
DOI Google Scholar
90

Escolano C, Aguilar M, Minguez J. EEG-based upper alpha neurofeedback training improves working memory performance. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2327-2330.
DOI Google Scholar
91
Gupta Meena, Bhatia Dinesh. Neurofeedback: retrain the brain. In: Early Detection of Neurological Disorders Using Machine Learning Systems. IGI Global; 2019:13-25
DOI
92

Biasiucci A, Leeb R, Iturrate I, et al. Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke. Nat Commun. 2018;9(1):2421.
DOI Google Scholar
93

Chowdhury A, Meena YK, Raza H, et al. Active physical practice followed by mental practice using BCI-driven hand exoskeleton: a pilot trial for clinical effectiveness and usability. IEEE JBiomedHeathInform. 2018;22(6):1786-1795.
DOI Google Scholar
94

Bai Z, Fong KNK, Zhang JJ, et al. Immediate and long-term effects of BCI-based rehabilitation of the upper extremity after stroke: a systematic review and meta-analysis. J Neuroeng Rehabil. 2020;17(1):57.
DOI Google Scholar
95

Behboodi A, Lee WA, Hinchberger VS, et al. Determining optimal mobile neurofeedback methods for motor neurorehabilitation in children and adults with non-progressive neurological disorders: a scoping review. J Neuroeng Rehabil. 2022;19(1):104.
DOI Google Scholar
96

Yoo JW, Lee DR, Sim YJ, et al. Effects of innovative virtual reality game and EMG biofeedback on neuromotor control in cerebral palsy. BiomedMaterEng. 2014;24(6):3613-3618.
DOI Google Scholar
97

Booth ATC, van der Krogt MM, Harlaar J, et al. Muscle Synergies in Response to Biofeedback-Driven Gait Adaptations in Children With Cerebral Palsy. Front Physiol. 2019;10:1208.
DOI Google Scholar
98

MacIntosh A, Lam E, Vigneron V, et al. Biofeedback interventions for individuals with cerebral palsy: a systematic review. DisabilRehabil. 2019;41(20):2369-2391.
DOI Google Scholar
99

MacIntosh, A., Vignais, N., & Biddiss, E. Biofeedback interventions for people with cerebral palsy: a systematic review protocol. Systematic reviews. 2017;6(1):3.
DOI Google Scholar
100

MacIntosh A, Desailly E, Vignais N, et al. A biofeedback-enhanced therapeutic exercise video game intervention for young people with cerebral palsy: A randomized single-case experimental design feasibility study. PLoS One. 2020;15(6):e0234767.
DOI Google Scholar
101

Ostojic K, Sharp N, Paget S, et al. BrightHearts: A pilot study of biofeedback assisted relaxation training for the management of chronic pain in children with cerebral palsy. Paediatr Neonatal Pain. 2021;4(1):34-43.
DOI Google Scholar
102

Masson R, Pagliano E, Baranello G. Efficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic review. DevMedChild Neurol. 2017;59(12):1237-1248.
DOI Google Scholar
103

Kanovsky P, Heinen F, Schroeder AS, et al. Safety and efficacy of repeat long-term incobotulinumtoxinA treatment for lower limb or combined upper/lower limb spasticity in children with cerebral palsy. J Pediatr Rehabil Med. 2022;15(1):113-127.
DOI Google Scholar
104

Dimitrova R, Kim H, Meilahn J, et al. Efficacy and safety of onabotulinumtoxinA with standardized physiotherapy for the treatment of pediatric lower limb spasticity: a randomized, placebo-controlled, phase III clinical trial. NeuroRehabilitation. 2022;50(1):33-46.
DOI Google Scholar
105

Heiss WD, Brainin M, Bornstein NM, et al. Cerebrolysin in patients with acute ischemic stroke in Asia. Stroke. 2012;43(3):630-636.
DOI Google Scholar
106

Pu HJ, Jiang XY, Hu XM, et al. Delayed docosahexaenoic acid treatment combined with dietary supplementation of Omega-3 fatty acids promotes long-term neurovascular restoration after ischemic stroke. Transl Stroke Res. 2016;7(6):521-534.
DOI Google Scholar
107

Leal-Martínez F, Franco D, Peña-Ruiz A, et al. Effect of a nutritional support system (diet and supplements) for improving gross motor function in cerebral palsy: an exploratory randomized controlled clinical trial. Foods. 2020;9(10):1449.
DOI Google Scholar
108

Yaqob K. P516 the positive clinical consequence of early intervention of combined therapy (omega 3 fatty acids and B12 vitamin) on children under 5 with variable forms of cerebral palsy. Arch Dis Child. 2019;104:A359-A360.
DOI Google Scholar
109

Nicolini-Panisson RD, Tedesco AP, Folle MR, Donadio MVF. Selective dorsal rhizotomy in cerebral palsy: selection criteria and postoperative physical therapy protocols. RIZOTOMIA dorsal SELETIVA NA PARALISIA cerebral: CRITÉRIOS de indicação E PROTOCOLOS de reabilitação fisioterapêutica pós-operatória. Rev Paul Pediatr. 2018;36(1):9.
DOI Google Scholar
110

Tedroff K, Hägglund G, Miller F. Long-term effects of selective dorsal rhizotomy in children with cerebral palsy: a systematic review. Dev Med Child Neurol. 2020;62(5):554-562.
DOI Google Scholar
111

Abel MF, Damiano DL, Pannunzio M, et al. Muscle-tendon surgery in diplegic cerebral palsy: functional and mechanical changes. J Pediatr Orthop. 1999;19(3):366-375.
DOI Google Scholar
112

Kuo CC, Huang HP, Lu HY, et al. Effects of tendon release surgery on inter-limb leg stiffness control in children with spastic diplegic cerebral palsy during gait. Appl Sci. 2021;11(10):4562.
DOI Google Scholar
113

Choi JY, Park ES, Park D, et al. Dynamic spasticity determines hamstring length and knee flexion angle during gait in children with spastic cerebral palsy. Gait Posture. 2018;64:255-259.
DOI Google Scholar
114

Nakagawa S, Mutsuzaki H, Mataki Y, et al. A new tendon-lengthening technique using a tendon stripper for knee flexion contracture in a cerebral palsy patient. J Orthop. 2020;18:110-112.
DOI Google Scholar
115

Lieber RL, Fridén J. Muscle contracture and passive mechanics in cerebral palsy. J Appl Physiol. 1985;126(5):1492-1501, 2019.
DOI Google Scholar
116

Kalkman BM, Bar-On L, Cenni F, et al. Muscle and tendon lengthening behaviour of the medial gastrocnemius during ankle joint rotation in children with cerebral palsy. ExpPhysiol. 2018;103(10):1367-1376.
DOI Google Scholar
117

Iwase D, Metoki Y, Aikawa J, et al. A modified sliding-lengthening approach to tendon lengthening with a locking mechanism suture: atechnical note. Indian J Orthop. 2023;57(3):505-509.
DOI Google Scholar
118

Reid SM, Carlin JB, Reddihough DS. Distribution of motor types in cerebral palsy: how do registry data compare? DevMedChild Neurol. 2011;53(3):233-238.
DOI Google Scholar
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Publication history

Received: 11 February 2023
Revised: 05 July 2023
Accepted: 12 July 2023
Published: 28 July 2023
Issue date: September 2023

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© 2023 The Author(s).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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