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So far many people still believe that there is a lack of effective drugs or strategies to restore the dysfunction and/or the damaged structure of refractory neurological diseases. However, neurorestorative treatments are being tried to change the state. Transplanted neural progenitor/precursor cells (NPCs) as a novel therapy strategy played an important role in promoting neurological function restoration. Evidence demonstrated that the positive effects of grafted NPCs were mediated mainly by the releasing paracrine factors, especially exosomes, which were derived from NPCs. Exosomes are important paracrine molecules involved in cellular functions and cell-cell communications. This standard was set up by the Chinese Association of Neurorestoratology (CANR; Preparatory) and the China Committee of International Association of Neurorestoratology (IANR-China Committee) to provide rational guidance for technological transformation and clinical applications. In this standard, we highlighted the nature and features of NPC-derived exosomes, aimed to integrate the production, education, and research on the clinical-grade NPC-derived exosomes, promote the relevant standards and regulations established by the government and promote to make the world professional standards.

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Publication history

Received: 10 November 2021
Revised: 05 January 2022
Accepted: 24 January 2022
Published: 10 May 2022
Issue date: June 2022

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© 2022 The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press.

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81671819 and 82171459) and the Natural Science Foundation of Guangdong Province (Grant Nos. 2019A1515012103 and 2021A1515010001).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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