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Editorial | Open Access

Turning shortcomings into advantages: The beauty of magnesium in orthopedic applications

Haozhi Zhanga,b,c, Ningze Zhangd, Ronald Man Yeung Wongd, Michael Tim Yun Ongd, Wenxue Tonga, Ling Qina( ), Jiankun Xua,c( )
Musculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chines University of Hong Kong, Hong Kong, Special Administrative Region of China
The Sir Yue-Kong Pao Cancer Centre, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region of China
Disruptive Innovation Centre for Spatiotemporal Imaging, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region of China
Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region of China

Peer review under the responsibility of Chongqing University.

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Abstract

Magnesium (Mg)-based biomaterials transform inherent limitations—rapid degradation and suboptimal strength—into therapeutic advantages for orthopedic regeneration. Contrary to industrial perceptions, the moderate corrosion rate and bone-mimetic stiffness (~30 GPa) of Mg synergistically support tissue repair: degradation products activate multiple pathways to enhance functional bone regeneration. Clinical translation milestones include China’s first NMPA-approved Mg-based 3D-printed scaffold. Future advancement hinges on three pillars: biomimetic structural design, material refinement, and smart implants. By redefining the “shortcomings” of Mg as regenerative assets, this paradigm accelerates functional bone reconstruction across orthopedic scenarios.

Keywords

MagnesiumOrthopedicsClinical translationBiomaterialsRegeneration medicine

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Journal of Magnesium and Alloys
Volume 14 Issue C,
January 2026
DOI: 10.1016/j.jma.2025.09.038

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Cite this article:
Zhang H, Zhang N, Wong RMY, et al. Turning shortcomings into advantages: The beauty of magnesium in orthopedic applications. Journal of Magnesium and Alloys, 2026, 14(C). https://doi.org/10.1016/j.jma.2025.09.038

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Received: 14 June 2025
Revised: 22 September 2025
Accepted: 28 September 2025
Published: 01 November 2025
© 2026 Chongqing University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)