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Letter | Open Access

Engineered ferritin nanocages for efficient siRNA delivery and potent gene silencing in plants

Han Zhang1,3,*, Ziyan Hu2,*, Xiangyu Bao1,*, Kun Wang1, Lijia Zheng4, Changqing Zhang3, Xueyong Yang1( ), Jiachen Zang2( ), Yuxuan Qin1( )
State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
College of Horticulture, China Agricultural University, Beijing 100193, China
Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China

* These authors contributed equally to this study.

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Highlights

• A bioinspired delivery platform using optimized 24-mer ferritin protein nanocages (FNCs) was developed to provide robust protection for siRNA against RNase-mediated degradation.

• The FNC platform effectively bypasses physical barriers, facilitating efficient internalization of siRNA into both the leaf and root tissues of Cucumis sativus and Arabidopsis thaliana.

• Potent non-transgenic gene silencing was achieved, with significant reductions in GFP reporter mRNA levels and fluorescence, providing a scalable framework for transient trait modification.

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Journal of Integrative Agriculture (JIA)
Volume 25 Issue 8,
August 2026
Pages 3498-3502
DOI: 10.1016/j.jia.2026.05.063

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Cite this article:
Zhang H, Hu Z, Bao X, et al. Engineered ferritin nanocages for efficient siRNA delivery and potent gene silencing in plants. Journal of Integrative Agriculture (JIA), 2026, 25(8): 3498-3502. https://doi.org/10.1016/j.jia.2026.05.063

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Received: 09 February 2026
Revised: 05 April 2026
Accepted: 17 April 2026
Published: 30 May 2026
© 2026 CAAS.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer review under responsibility of Editorial Board of Journal of Integrative Agriculture.