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Letter | Open Access

Coronavirus-like particles package the negative-strand genome of coronavirus

Xinyu Yang*, Wenzhen Qin*, Ning Kong*, Yuchang Liu, Guangzhi Tong, Tongling Shan( )
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China

* These authors contributed equally to this study.

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Highlights

• The particles of coronavirus package the negative-sense genome of coronavirus into the coronavirus-like particles.

• In PEDV particles purified by sucrose density gradient centrifugation and treated with antibodies and nuclease, approximately 20 to 46% contain negative-sense genomes.

• Coronavirus-like particles are capable of adsorption and internalization.

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Journal of Integrative Agriculture (JIA)
Volume 25 Issue 8,
August 2026
Pages 3508-3510
DOI: 10.1016/j.jia.2025.12.042

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Cite this article:
Yang X, Qin W, Kong N, et al. Coronavirus-like particles package the negative-strand genome of coronavirus. Journal of Integrative Agriculture (JIA), 2026, 25(8): 3508-3510. https://doi.org/10.1016/j.jia.2025.12.042

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Received: 28 September 2025
Revised: 05 November 2025
Accepted: 25 November 2025
Published: 22 December 2025
© 2026 CAAS.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer review under responsibility of Editorial Board of Journal of Integrative Agriculture.