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Review | Open Access

Functional genes associated with the occurrence of mycotoxins produced by Aspergillus in foods

Mei Gu1Can Liu1Xiaofeng Yue1Du Wang1Xiaoqian Tang1Qi Zhang1,2,3( )Peiwu Li1,2,3,4( )
Key Laboratory of Biology and Genetic Improvement of Oil Crops and Key Laboratory of Detection for Mycotoxins of Ministry of Agriculture and Rural Affairs/Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430061, China
Institute of Food Safety, Hubei University, Wuhan 430061, China
Hubei Hongshan Laboratory, Wuhan 430061, China
Xianghu Laboratory, Hangzhou 311231, China
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Highlights

• This review provides a comprehensive summary of the genes involved in aflatoxin biosynthesis and constructs the regulatory network governing toxin production, offering new insights for the development of aflatoxin control strategies.

• It also systematically summarizes the functions of key genes regulating the growth and development of Aspergillus species, thereby laying a theoretical foundation for the development of source-level control technologies against Aspergillus.

Abstract

Aspergillus species are ubiquitous fungi that produce mycotoxins (secondary metabolites) known as sterigmatocystin and aflatoxins in many different kinds of foods, which leads to serious contamination in agricultural products, thereby endangering human health. Extensive studies on Aspergillus fungi have been conducted on growth and development, aflatoxin biosynthesis, and their interactions with environment. Here, we summarized a series of functional genes of the main Aspergillus fungi relative to toxins occurrence in foods, which revealed the signal transduction mechanisms of their involvement in growth and development, toxin production, and response to light, anticipating providing theoretical guidance on developing control and prevention technologies for mycotoxin contamination in agricultural products to ensure food safety.

References

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Journal of Integrative Agriculture (JIA)
Pages 585-601

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Cite this article:
Gu M, Liu C, Yue X, et al. Functional genes associated with the occurrence of mycotoxins produced by Aspergillus in foods. Journal of Integrative Agriculture (JIA), 2026, 25(2): 585-601. https://doi.org/10.1016/j.jia.2025.10.017

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Received: 18 March 2025
Revised: 08 July 2025
Accepted: 13 September 2025
Published: 01 November 2025
© 2026 CAAS.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer review under responsibility of Editorial Board of Journal of Integrative Agriculture.